Results 91 to 100 of about 81,793 (268)

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

open access: yes
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai   +4 more
wiley   +1 more source

Extreme Heterophilic Antibody Interference in BNP Immunoassay: A Case Report and Systematic Investigation Protocol

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
A 53 year‐old male with type 2 diabetes presented extremely elevated BNP (> 4000 pg/mL) but normal NT‐proBNP and cardiac function. Systematic verification confirmed severe heterophilic antibody (HAMA) interference in the BNP chemiluminescence immunoassay.
Huicong Yang   +6 more
wiley   +1 more source

Ras, Akt, and Mechanotransduction in the Cardiac Myocyte [PDF]

open access: yesCirculation Research, 2003
The Ras subfamily of 21-kDa (“small”) guanine nucleotide binding proteins [which includes Ha-Ras, Ki(A)-Ras, Ki(B)-Ras, and N-Ras] is universally important in regulating intracellular signaling events in mammalian cells and controls their growth, proliferation, senescence, differentiation, and survival.
openaire   +2 more sources

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay   +3 more
wiley   +1 more source

The impairment of ILK related angiogenesis involved in cardiac maladaptation after infarction.

open access: yesPLoS ONE, 2011
BackgroundIntegrin linked kinase (ILK), as an important component of mechanical stretch sensor, can initiate cellular signaling response in the heart when cardiac preload increases.
Jun Xie   +6 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli   +5 more
wiley   +1 more source

Comparative Performance Analysis of an Open Source Motion‐Compensated Cardiac Diffusion Sequence Across Different MRI Systems and Gradient Strengths—A Pilot Study

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To validate the performance of an open‐source cardiac diffusion sequence framework and to investigate hardware‐based performance differences. Methods Three second order motion compensated sequence files were compiled using Pulseq and applied across different MRI systems to image five volunteers.
Eric Arbes   +7 more
wiley   +1 more source

Carboxy-terminal 24-amino-acid peptide of integral membrane protein 2A is produced in the heart and stimulates atrial natriuretic peptide release

open access: yesScientific Reports
Humoral factors regulating cardiac myocytes have not yet been fully elucidated. Using mass spectrometry, we analyzed peptides released from primary neonatal rat cardiac fibroblasts to identify a 24-amino-acid peptide with an intramolecular disulfide bond.
Tsukasa Osaki   +11 more
doaj   +1 more source

A Platform for the Actuation of Magnetically Labeled Skeletal Muscle Cells Using Dynamic Magnetic Stimulation

open access: yesSmall, EarlyView.
A magnetic stimulation platform for the remote stimulation of cells is presented, consisting of a magnetic stimulator and magnetic microspheres. Skeletal muscle cells are labeled with magnetic microspheres, which act as local magnetic actuators on the cells upon application of the magnetic field.
Tayná C. Rodrigues   +14 more
wiley   +1 more source

Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy

open access: yesMolecular Therapy: Nucleic Acids, 2013
RNA trans-splicing has been explored as a therapeutic option for a variety of genetic diseases, but not for cardiac genetic disease. Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease, characterized by left ventricular hypertrophy (LVH ...
Giulia Mearini   +13 more
doaj   +1 more source

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