Results 261 to 270 of about 78,026 (273)
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How to isolate cardiac myocytes
Cardiovascular Research, 1994A complete technique is described for the isolation of myocytes from mammalian hearts using the Langendorff perfusion technique. The use of calcium-free solution containing collagenase and protease, followed by low calcium solution, consistently results in a large number of calcium tolerant myocytes which are well suited for long periods of ...
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Engineering design of a cardiac myocyte [PDF]
Journal of Computer-Aided Materials Design, 2007 We describe a design algorithm to build a cardiac myocyte with specific spatial dimensions and physiological function. Using a computational model of a cardiac muscle cell, we modeled calcium (Ca 2+ ) wave dynamics in a cardiac myocyte withcontrolledspatialdimensions.Themodeledmyocytewasreplicatedinvitrowhen ...
Terrence Pong +5 more
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Scaffolding Proteins in Cardiac Myocytes
2008Post-translational modification, such as protein phosphorylation, plays a critical role to reversibly amplify and modulate signaling pathways. Since kinases and phosphatases have broad substrate recognition motifs, compartmentalization and localization of signaling complexes are required to achieve specific signals.
N. L. Chudasama +2 more
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Confocal Microscopy of Cardiac Myocytes
2013Detailed methods are provided for the preparation and confocal imaging of cardiac myocyte development and differentiation. Examples include protocols for the analysis of cultured myocytes as well as vibratome sections of hearts from embryonic and adult tissue.
Stephen T. Haley +5 more
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Cardiac Myocyte Terminal Differentiation
Annals of the New York Academy of Sciences, 1995The exact mechanism of terminal differentiation in cardiac myocytes is currently unknown. Studies in the skeletal muscle system provided a model where muscle lineage termination gene directly interacts with Rb to produce and maintain the terminally differentiated state. This interaction provided the critical components for the lock in cell cycle arrest
Wei Gu +3 more
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The association of lysophosphatidylcholine with isolated cardiac myocytes
Lipids, 1990AbstractThe ability of exogenous lysophosphatidylcholine to produce electrophysiological derangements and cardiac arrhythmias in the heart has been documented. The action of lysophosphatidylcholine is thought to be mediated via its association with the membrane.
Man, RYK +3 more
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Hamartoma of mature cardiac myocytes*1, *2
Human Pathology, 1998The clinical and pathological findings of three patients with hamartomas of mature cardiac myocytes resembling localized hypertrophic cardiomyopathy are presented. Hypertrophic cardiomyopathy is manifest by a poorly demarcated area of cardiac hypertrophy, microscopically demonstrating myofiber disarray and intramural coronary thickening.
Allen P. Burke +5 more
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Calcium and the Injured Cardiac Myocyte
1984Injured cardiac myocytes accumulate Ca2+. It does not seem to matter whether the injury is due to reperfusion after prolonged periods of normothermic ischemia [1, 2], sustained hypoxia [3], a naturally occurring cardiomyopathy, or the reintroduction of Ca2+ after only a few minutes of Ca2+-free perfusion [4–6], the end result is the same—that is, the ...
Winifred G. Nayler, M.J. Daly
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Leptofibrils in Cardiac Myocytes
Ultrastructural Pathology, 1988Eloisa Arbustini +3 more
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Calcium signalling in cardiac myocytes
2012Calcium signalling in cardiac myocytes consists of a basic scaffold of four molecular entities: the voltage-activated calcium channel and sodium-calcium exchanger (NCX) in the plasma membrane and the ryanodine receptor (Ry R) and the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) in the membrane of the sarcoplasmic reticulum.
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