Results 241 to 250 of about 94,921 (285)

Primary Solitary Intra-thyroid Myofibroma in a Pediatric Patient. [PDF]

Cureus
Jensen L, Silva G, Westmoreland T, Miles L.   +3 more
europepmc   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Aging and Intestinal Fibrosis: Mechanisms, Implications, and Therapeutic Strategies. [PDF]

Clin Interv Aging
Shi Y, Zheng H, Zhu X, Lv J, Zhou M, Zhang S.   +5 more
europepmc   +1 more source

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Pulmonary-Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy. [PDF]

Adv Sci (Weinh)
Li XN, Lin YP, Ma XX, Fang YF, Wang H, Cui CH, Zhang C, Piao JY, Jeong JH, Cheng XW, Xing L, Jiang HL.   +11 more
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Substrate stiffness modulates phenotype-dependent fibroblast contractility and migration independent of TGF-<i>β</i> stimulation. [PDF]

Mechanobiol Med
D'Urso M, van den Bersselaar P, Pragnere S, Maiuri P, Bouten CVC, Kurniawan NA.   +5 more
europepmc   +1 more source

RDYH58 functional exosomes targeting myofibroblasts loaded with siFKBP10 for inhibition of collagen biosynthesis and secretion of IPF. [PDF]

Acta Pharm Sin B
Yuan R, Mu Z, Zhang H, Tian Y, Xin Q, Tu Q, Zhang Y, Li Y, Zhang Z, Chu Y, Wang A, Tian J, Wang H, Qiu C, Shi Y.   +14 more
europepmc   +1 more source

Bio-tensegrity and extracellular matrix disruption in the pathogenesis of persistent post-operative pain: a hypothesis. [PDF]

Front Physiol
Plaut S.
europepmc   +1 more source