Results 121 to 130 of about 182,656 (351)

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy [PDF]

, 2018
Kassandra L. Munger, Alberto Ascherio, E Liotta, S Prabhakaran, R Sangha, M Lopresti, S Bruce, E Camacho, I Anik, H Secer, Y Anik, B Duz, E Gonul, E Liotta, S Prabhakaran, R Sangha, M Maas, M Berman, J Guth, A Naidech, R Bernstein, S Bassin, K Munger, K Hongell, J Aivo, R Tonnesen, P Hovind, L Jensen, P Schwarz, A Hedstrom, M Baarnhielm, T Olsson, L Alfredsson, K Munger, J Aivo, K Hongell, M Stein, Y Liu, O Gray, K Munger, K Hongell, J Aivo, A Ascherio, K Munger, A Hill, L Mokry, S Ross, O Ahmad, B Rhead, M Baarnhielm, M Gianfrancesco, A Karaa, R Haas, A Goldstein   +53 more
openalex   +1 more source

Improved Detection of Myositis‐Specific Autoantibodies Using Luciferase Immunoprecipitation Systems Assay: Comparison with Line Blot and Conventional Immunoprecipitation

Arthritis &Rheumatology, Accepted Article.
Background Myositis‐specific autoantibodies guide the diagnosis and classification of idiopathic inflammatory myopathies, but current immunoassays vary in accuracy, particularly for autoantibodies associated with interstitial lung disease. Objective To compare the performance of the luciferase immunoprecipitation systems (LIPS) assay with line blot and
Peter D. Burbelo, Iago Pinal‐Fernandez, Maria Casal‐Dominguez, Xin Tian, Shijinqiu Gao, Neha Gupta, Eric Robbins, John A. Chiorini, Christopher A. Mecoli, Lisa Christopher‐Stine, Livia Casciola‐Rosen, Andrew Mammen, Sonye K. Danoff, Anthony F. Suffredini, Julio A. Huapaya   +14 more
wiley   +1 more source

Interleukin‐2 deprived state of regulatory T cells and their recovery by low‐dose interleukin‐2 in patients with inflammatory myopathies

Arthritis &Rheumatology, Accepted Article.
Objective Regeneration and expansion of regulatory T cells (Treg) by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg‐IL‐2 axis emerge in ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy

Cardiovascular Ultrasound
Background Left atrial (LA) and ventricular (LV) functional impairment often co-exist in patients with heart failure (HF). However, some patients with HF have a disproportionate LA or LV dysfunction.
Xuanyi Jin, Wan Ting Tay, Dinna Soon, David Sim, Seet Yoong Loh, Sheldon Lee, Fazlur Jaufeerally, Lieng Hsi Ling, A. Mark Richards, Adriaan A. Voors, Carolyn S. P. Lam, Joost P. van Melle   +11 more
doaj   +1 more source

Progressive myopathy in an inducible mouse model of oculopharyngeal muscular dystrophy

Neurobiology of Disease, 2012
The genetic basis of oculopharyngeal muscular dystrophy (OPMD) is a short expansion of a polyalanine tract (normal allele: 10 alanines, mutant allele: 11–17 alanines) in the nuclear polyadenylate binding protein PABPN1 which is essential for controlling ...
Ami Mankodi, Thurman M. Wheeler, Reena Shetty, Kelly M. Salceies, Mark W. Becher, Charles A. Thornton   +5 more
doaj   +1 more source

Author response for "Correlation between instrumental stress and oral processing property of chicken broiler breast under wooden breast myopathy"

, 2021
Yulong Zhang, Yunfan Gao, Zhen Li, Zimeng Zheng, Xinglian Xu, Peng Wang, Bin Zheng, Zexin Qi   +7 more
openalex   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Oculopharyngeal myopathy with distal and cardiomyopathy. [PDF]

, 1977
Itaru Goto, Yukiko Kanazawa, T Kobayashi, Y Murai, Yoshigoro Kuroiwa   +4 more
openalex   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source