Results 171 to 180 of about 49,142 (262)

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Symptoms of Depression and Anxiety among Myopes: A Systematic Review and Meta-Analysis. [PDF]

Br Ir Orthopt J
Kyei S, Asiamah R, Owusu G, Ampiah EE.
europepmc   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Editorial: Myopia in childhood and adolescence. [PDF]

Front Ophthalmol (Lausanne)
Cruz-Gálvez CC, Ordaz-Favila JC, Bosch-Canto V.   +2 more
europepmc   +1 more source

Top Managerial Network Relations for Knowledge Transfer: Exploring Gender Differences

Creativity and Innovation Management, EarlyView.
ABSTRACT In the ongoing debate surrounding the gender gap in top managerial positions, various possible causes have been explored, with different networking patterns being one of them. However, we still lack detailed insights on how knowledge transfer via networks varies based on gender.
Sonja Sperber, Christian Linder
wiley   +1 more source

Clinical spectrum and prevalence associations of chorioretinal damage in high myopia: a retrospective cross-sectional analysis. [PDF]

Front Med (Lausanne)
Li G, Wang Y, Chen X.
europepmc   +1 more source

Duration‐Dependent Efficacy and Clinical Safety of Repeated Low‐Level Red‐Light Therapy for Paediatric Myopia: A Systematic Review and Meta‐Analysis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Repeated low‐level red‐light (RLRL) therapy is a novel, non‐invasive intervention for controlling paediatric myopia progression. Despite increasing clinical use, questions remain regarding the magnitude, durability, and safety of treatment effects.
Lee‐Yuan Lin, Cheng‐Hao Hsu, Hung Su, Jia‐Wei Sun, Jie‐Syuan Wu, Wei‐Jung Jeng, Chen‐Hsin Tsai, Fara Silvia Yuliani, Shyh‐Hsiang Lin   +8 more
wiley   +1 more source

Light and myopia: a focus on the expanding role of non-visual opsins. [PDF]

Eye Vis (Lond)
Gettinger K, Tsubota K, Negishi K, Kurihara T.   +3 more
europepmc   +1 more source

‘I Do Not Feel Great About It, but It Was the Logical Decision’—An Exploration of Why England's Agency Social Workers Have Left Permanent Child Protection Roles

Child &Family Social Work, EarlyView.
ABSTRACT In 2023, England's statutory children's services recorded the highest number of agency social workers since records began. The cost of these workers, and the impact of an unsettled workforce on the children in receipt of their services, has led to a new set of national rules for agency social workers in children's social care.
Ciarán Murphy
wiley   +1 more source