Results 141 to 150 of about 843 (162)

[Myotonin protein kinase].

Rinsho shinkeigaku = Clinical neurology, 1996
The mutation underlying myotonic dystrophy is the expansion of polymorphic CTG repeat in the 3'-noncoding region of the myotonin protein kinase (MtPK) gene mapping to chromosome 19q13.3. A full-length cDNA of human MtPK was cloned and expressed in COS-1 cells.
S, Ishiura, N, Sasagawa, N, Saitoh, H, Koike, H, Sorimachi, K, Suzuki, M, Shimokawa, F, Usuki, H, Nakase, K, Kamakura   +9 more
openaire   +1 more source

[CTG-repeat in myotonin protein kinase].

Rinsho shinkeigaku = Clinical neurology, 1995
Myotonic dystrophy (DM) is one of the most common inherited neuromuscular diseases in adults with a global incidence of 1 in 20,000 individuals. DM is an autosomal dominant disorder characterized primarily by myotonia and progressive muscle weakness. DM has unique genetic feature of anticipation, that is, increasing disease severity from generation to ...
H, Sorimachi, N, Sasagawa, K, Maruyama, K, Arahata, S, Ishiura, K, Suzuki   +5 more
openaire   +1 more source

[Physiological function of myotonin protein kinase].

Nihon rinsho. Japanese journal of clinical medicine, 1998
The mutation underlying myotonic dystrophy is the expansion of polymorphic CTG repeat in the 3'-noncoding region of the myotonin protein kinase (MtPK) gene mapping to chromosome 19q13.3. A full-length cDNA of human MtPK was cloned and expressed in COS-1 cells. We purified native full-length MtPK from rat skeletal muscle.
openaire   +1 more source

[Population analysis CTG trinucleotide repeats in the myotonin-protein kinase I gene].

Genetika, 1998
CTG trinucleotide repeat length polymorphism within the 3' region of the myotonin protein kinase I (MP-I) gene was examined with the use of the polymerase chain reaction (PCR) technique. A total of 159 DNA samples from healthy donors from five ethnic groups including Russians (n = 33), Azerbaijanians (n = 29), Uzbeks (n = 31), Moldavians (n = 31), and ...
T E, Ivashchenko, P B, Glazkov, N N, Khromov-Borisov, V S, Baranov   +3 more
openaire   +1 more source

[Cataract as an only clinical manifestation of myotonic dystrophy--a new example of somatic instability of CTG repeats expansion in myotonin protein kinase gene].

Rinsho shinkeigaku = Clinical neurology, 1998
We reported a 69-year-old woman who developed a cataract as a single clinical expression of myotonic dystrophy (MD). There are many MD patients in her family including her 29-year-old daughter suffering from congenital MD. We compared CTG repeats expansion in the motonin protein kinase gene from the lens obtained at operation with that of her and her ...
Y, Saito, K, Sato, M, Kawai
openaire   +1 more source

Myotonic Dystrophy Protein Kinase [ DMPK or Myotonin Protein Kinase ( Mt PK )]

, 2002
Noboru Sasagawa, Shoichi Ishiura
openalex   +1 more source

Characterization of a 54-kilodalton human protein kinase recognized by an antiserum raised against the myotonin kinase

, 1998
Pierre Etongu�-Mayer, Robert Faure, Jean‐Pierre Bouchard, Jack Puymirat   +3 more
openalex   +2 more sources

Rho kinase, a promising drug target for neurological disorders

Nature Reviews Drug Discovery, 2005
Nicole Teusch
exaly  

Targeting innate immunity protein kinase signalling in inflammation

Nature Reviews Drug Discovery, 2009
Matthias Gaestel, Michael Kracht
exaly  

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

Nature Reviews Drug Discovery, 2009
Pasi A Jänne
exaly