Results 131 to 140 of about 10,687,918 (152)

Myotubularin-Related (MTMR) Phospholipid Phosphatase Proteins in the Peripheral Nervous System

Molecular Neurobiology, 2007
Myotubularin-related proteins (MTMRs) constitute a broad family of ubiquitously expressed phosphatases with 14 members in humans, of which eight are catalytically active phosphatases, while six are catalytically inactive. Active MTMRs possess 3-phosphatase activity toward both PtdIns3P and PtdIns(3, 5)P 2 poliphosphoinositides (PPIn), suggesting an ...
Bolis A, Zordan P, Coviello S, Bolino A
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Receptor Mediated Endocytosis 8 Is a Novel PI(3)P Binding Protein Regulated by Myotubularin-Related 2 [PDF]

FEBS Letters, 2011
Myotubularin related protein 2 (MTMR2) is a member of the myotubularin family of phosphoinositide lipid phosphatases. Although MTMR2 dephosphorylates the phosphoinositides PI(3)P and PI(3,5)P2, the phosphoinositide binding proteins that are regulated by MTMR2 are poorly characterized.
Panayiotis O Vacratsis, Besa Xhabija, Gregory S Taylor   +2 more
exaly   +3 more sources

Abstract B031: Inhibition of mutant RAS via myotubularin related protein 7-mimicking peptide

Molecular Cancer Research, 2023
Abstract The coiled coil domain of Myotubularin Related Protein 7 (MTMR7) and a peptide of the same sequence (M7CC) have been shown to have an anti-cancer effect via direct interaction with PPARγ (Weidner et al. 2020). The same studies also found an inhibition of ERK-mediated inactivation of PPARγ by the same peptide.
Daniel Saar, Philip Weidner, Elke Burgermeister, Birthe B. Kragelund   +3 more
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Myotubularin-Related-Protein-7 Inhibits Mutant (G12V) K-RAS by Direct Interaction

Cancer Letters
ISSN:0304 ...
Daniel Saar, Yu Yanxiong, Rony Seger
exaly   +5 more sources

Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast

Biochemical and Biophysical Research Communications, 2017
Myotubularin related protein 7 (MTMR7) is a key member of the highly conserved myotubularin related proteins (MTMRs) family, which has phosphatase activity. MTMR7 was increased during myoblast differentiation and exhibited high expression level at primary fibers formation stages in pigs. This suggests that MTMR7 may be involved in myogenesis.
Zhuning Yuan, Yaosheng Chen, Xumeng Zhang, Xingyu Zhou, Mingsen Li, Hu Chen, Ming Wu, Ying Zhang, Delin Mo   +8 more
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Wnt Signalling Requires MTM‐6 and MTM‐9 Myotubularin Lipid‐Phosphatase Function in Wnt‐Producing Cells [PDF]

EMBO Journal, 2010
Wnt proteins are lipid-modified glycoproteins that have important roles in development, adult tissue homeostasis and disease. Secretion of Wnt proteins from producing cells is mediated by the Wnt-binding protein MIG-14/Wls, which binds Wnt in the Golgi ...
Hendrik C Korswagen, Fillip Port, Martin Harterink   +2 more
exaly   +2 more sources

Myotubularin-related protein 6 is an ion channel-associated pro-leishmanial phosphatase

International Immunopharmacology
Residing obligatorily as amastigotes within the mammalian macrophages, the parasite Leishmania donovani inflicts the potentially fatal, globally re-emerging disease visceral leishmaniasis (VL) by altering intracellular signaling through kinases and phosphatases.
Shabina Parveen, Saikat Majumder, Neelam Bodhale, Nihar Ranjan Biswal, Surya Prakash Pandey, Aritri Dutta, Pradyumna Patra, Suchandra Bhattacharya-Majumdar, Chiranjib Pal, Subrata Majumdar, Bhaskar Saha   +10 more
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Myotubularin-related protein-6 silencing protects mice from Leishmania donovani infection

International Immunopharmacology
The protozoan parasite Leishmania donovani resides within mammalian macrophages and alters its antigen-presenting functions to negatively regulate host-protective T cell responses. This negative regulation of human T cell responses in vitro is attributed to myotubularin-related protein-6 (MTMR6), an ion channel-associated phosphatase.
Mukesh Kumar, Jha, Himanshu Singh, Chandel, Surya Prakash, Pandey, Aditya, Sarode, Neelam, Bodhale, Suchandra, Bhattacharya-Majumdar, Subrata, Majumdar, Bhaskar, Saha   +7 more
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MiR‐99a exerts anti‐metastasis through inhibiting myotubularin‐related protein 3 expression in oral cancer

Oral Diseases, 2013
ObjectiveWe aimed at studying the role of the most deregulated miR‐99a, identifying its downstream targets, and exploring the clinical potential of miR‐99a and its target(s) in oral cancer.Subjects and MethodsFollowing confirmation of miR‐99a deregulation in nine oral lines and 26 pairwise clinical specimens, miR‐99a‐manipulated oral cancer cells were ...
Y Z, Kuo, Y H, Tai, H I, Lo, Y L, Chen, H C, Cheng, W Y, Fang, S H, Lin, C L, Yang, S T, Tsai, L W, Wu   +9 more
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Characterisation of the 3-phosphatase myotubularin-related protein 4 (mtmr4) in breast cancer

2017
Abstract withheld by ...
openaire   +1 more source