Results 161 to 170 of about 22,681 (186)

Head and neck pleomorphic myxoid liposarcoma in a child with Li-Fraumeni syndrome

International Journal of Pediatric Otorhinolaryngology, 2019
Pleomorphic myxoid liposarcoma is a rare and aggressive cancer seen in the pediatric population that has been previously associated with hereditable cancer disorders like Li Fraumeni syndrome. We present a case report and review of the relevant literature.Pleomorphic myxoid liposarcoma presenting as a second primary tumor in a child with a strong ...
Mark Lovell, Brian William Herrmann
exaly   +3 more sources

Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near‐haploidization and loss of the RB1 gene

Histopathology, 2016
AimsPleomorphic myxoid liposarcoma (PML) is an exceptionally rare and poorly studied subtype of liposarcoma, occurring typically in children and adolescents. The few previous genetic studies have shown that PML lacks the gene fusions and amplifications that characterize myxoid liposarcoma, atypical lipomatous tumour and de‐differentiated liposarcoma ...
Jakob, Hofvander, Vickie Y, Jo, Iman, Ghanei, David, Gisselsson, Emma, Mårtensson, Fredrik, Mertens   +5 more
openaire   +3 more sources

A Case of Myxoid Pleomorphic Liposarcoma with Rhabdoid Cells: A Diagnostic Pitfall

International Journal of Surgical Pathology
Myxoid pleomorphic liposarcoma (MPLS) is an extremely rare tumor listed in the fifth edition of the WHO classification (2020). Histologically, it mainly comprises a mixture of myxoid and pleomorphic liposarcoma-like components. Genetically, it lacks FUS/EWSR1::DDIT3 fusion and MDM2 amplification.
Ikuma Kato
exaly   +3 more sources

Array-based comparative genomic hybridisation analysis of a pleomorphic myxoid liposarcoma

Journal of Clinical Pathology, 2014
Pleomorphic myxoid liposarcoma, first described and defined by Alaggio et al 1 ,2 as a neoplasm showing mixed distinctive histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and usually occurring in young patients, is a very rare and still poorly explored and under-recognised tumour entity.
David Creytens, Louis Libbrecht, Nadine van Roy   +2 more
exaly   +2 more sources

Fine-needle aspiration in liposarcoma: Cytohistologic correlative study including well-differentiated, myxoid, and pleomorphic variants

Diagnostic Cytopathology, 2004
AbstractWe have reviewed cytopathology and the corresponding histopathology material of 86 liposarcomas (55 patients) seen at Institut Curie. The liposarcomas (LS) were well differentiated in 14 cases (9 pure, 2 dedifferentiated, 3 sclerosing), 64 myxoid, and 8 pleomorphic. Twenty‐four tumors were primary, 34 recurrent, and 28 secondary.
Real Lagacé, Jean-Michel Caillaud
exaly   +3 more sources

Rare myxoid pleomorphic liposarcoma: a case report and literature review

Journal of Clinical Pathology, 2023
We report a case of a middle-aged woman with a rapidly growing abdominal mass that was diagnosed as myxoid pleomorphic liposarcoma, a recently recognised, rare and aggressive subtype of liposarcoma. The tumour exhibits a combination of histological features from both myxoid liposarcoma and pleomorphic liposarcoma.
Yanying Shen, Ling Zhao, Anqi Li, Qi Peng, Qiang Liu, Lisha Wang, Zebing Liu   +6 more
openaire   +2 more sources

Recurrent Pleomorphic Myxoid Liposarcoma in a Patient With Li-Fraumeni Syndrome

International Journal of Surgical Pathology, 2019
Pleomorphic myxoid liposarcoma is an extremely rare, clinically aggressive subtype of liposarcoma that has been primarily reported in young patients. In this article, we report a case of a pleomorphic myxoid liposarcoma that presented as a second primary neoplasm in a 34-year-old man with history of primary mediastinal large B-cell lymphoma. During the
Somaye Y. Zare, Mariah Leivo, Oluwole Fadare   +2 more
openaire   +2 more sources

[Systemic Therapy Options for Locally Advanced and Metastatic Myxoid, Dedifferentiated and Pleomorphic Liposarcoma].

Zentralblatt fur Chirurgie, 2020
Just a few years ago, all patients with metastatic soft tissue sarcoma received the same chemotherapy drugs. However, it is now recognised that the various sarcoma subtypes are different tumours with distinct genetic alterations and different biological behaviour, so that histology-specific treatment protocols have been increasingly implemented in ...
Daniel, Pink, Antje, West, Dimosthenis, Andreou   +2 more
openaire   +2 more sources

Myxoid liposarcoma with pleomorphic cells: Report of two cases with molecular confirmation of FUS gene rearrangements

Pathology - Research and Practice, 2016
Myxoid liposarcoma is usually composed of uniform oval to short spindle cells in a prominent myxoid stroma. We report here two cases of myxoid liposarcoma containing unusual pleomorphic cells harboring FUS gene rearrangements. One of the lesions arose in the right loin of a 70-year-old man, while the other in the right upper arm of a 73-year-old woman.
Kazuyoshi, Uchihashi, Atsuji, Matsuyama, Masamichi, Nakayama, Akio, Sakamoto, Eisuke, Shiba, Masanori, Hisaoka   +5 more
openaire   +2 more sources

The 12q13‐q15 translocation breakpoints in pleomorphic adenoma and clear‐cell sarcoma of tendons and aponeuroses are different from that in myxoid liposarcoma

Genes, Chromosomes and Cancer, 1993
AbstractThe transcription factor gene CHOP was recently shown to be rearranged in myxoid liposarcoma with t(12;16)(q13;p11). We have analyzed whether the CHOP gene is the target of rearrangements in pleomorphic adenoma and clear‐cell sarcoma of tendons and aponeuroses with chromosome abnormalities of 12q13‐q15. Restriction fragment analysis showed that
G, Stenman, P, Sahlin, J, Mark, R S, Chaganti, L G, Kindblom, P, Aman   +5 more
openaire   +2 more sources