Results 141 to 150 of about 585,553 (296)

A flor e a náusea: o princípio da legalidade no absolutismo ilustrado português

Boletim IBCCRIM
Este artigo investiga um precoce precedente jurídico do princípio da legalidade penal no direito português: um assento da Suplicação de meados do século XVIII.
Nilo Batista
doaj   +1 more source

Via régia [PDF]

, 2014
Via Régia é um trabalho sobre a violência da linguagem na obra de Peter Handke. "R.S.I." ou "O Discurso da Histérica", a partir de Self-Accusation de Peter Handke é uma performance solo com a duração de 27 minutos; ABSTRACT: Via Régia is a work about ...
Nunes, Susana Gonçalves
core  

A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers.

Anesthesiology, 1999
C. Apfel, E. Läärä, M. Koivuranta, C. Greim, N. Roewer   +4 more
semanticscholar   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Antiemetic effect of acupressure wristbands for GLP-1 medication associated nausea

Obesity Pillars
Background: Nausea is one of the most reported side effect of GLP-1 receptor agonists (GLP-1a). Current recommendations fall short in taming the symptoms, include antiemetic medication, behavior changes, GLP-1a dose adjustment, and often cause a ...
Florencia Ziemke, Soufiane Belarj, Jem Esguerra, Anita Reyes, Nawfal Istfan   +4 more
doaj   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

“COMPARACIÓN DE LA EFICACIA ANALGÉSICA DE 30 MG DE BUPRENORFINA TRANSDÉRMICA APLICADA 12 O 24 HRS ANTES DE LA CIRUGÍA EN 70 PACIENTES POSTOPERADAS DE HISTERECTOMÍA TOTAL ABDOMINAL EN EL HOSPITAL MATERNO INFANTIL ISSEMYM TOLUCA” [PDF]

, 2013
Estudios previos reportan en las primeras 24 horas posquir̼rgicas 40% de los pacientes presentan algún grado de dolor de moderado a intenso, y hasta un 65% tiene un manejo subóptimo.
Hernández Contreras, José Felipe, Quezada Báez, Cynthia Lizet   +1 more
core  

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source