Results 51 to 60 of about 3,495 (229)

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

open access: yesAdvanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu   +10 more
wiley   +1 more source

Síndrome de Lev Lenegre [PDF]

open access: yes, 2012
O nó sinusal, também chamado de nó sinoatrial, é uma estrutura formada por fibras cardíacas modificadas, especializadas, localizada na junção do átrio direito com a veia cava superior. Ele faz parte da rede elétrica cardíaca e é de grande importância por
Camara, G.   +9 more
core   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

open access: yesAdvanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng   +6 more
wiley   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

open access: yesAdvanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen   +6 more
wiley   +1 more source

Condição periodontal de pacientes com relato de doenças e/ou eventos cardiovasculares tratados nas clínicas odontológicas da Universidade Federal de Santa Catarina [PDF]

open access: yes, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.A doença periodontal é um das enfermidades bucais mais prevalentes no Brasil e no mundo. Sua etiologia é multifatorial e o papel da modulação do hospedeiro
Brum, Renata Scheeren
core  

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

open access: yesAdvanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan   +9 more
wiley   +1 more source

Electrofisiologia clínica do nó sinusal [PDF]

open access: yes, 1989
Dissertação de Doutoramento em Medicina, área de especialização em Medicina Interna, apresentada à Faculdade de Medicina da Universidade do ...
Cunha, Damião José Gaspar Lourenço da
core  

Emergency Cholecystectomy in Patients Classified as High Risk According to the Tokyo Guidelines 2018: A Real‐World Analysis

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Emergency cholecystectomy was evaluated in patients with acute cholecystitis classified as non‐recommended for surgery by the Tokyo Guidelines 2018. Major postoperative complications, rather than mortality, better reflected operative risk. Physiological instability, particularly ASA‐PS ≥ 3 and shock status, identified high‐risk patients, suggesting ...
Satoshi Mii   +9 more
wiley   +1 more source

Estado atual da estimulação cardíaca artificial [PDF]

open access: yes, 1986
Artificial cardiac stimulation is the best choice to treat sintomatic and severe bradiarrithmas. It is indicated in sick sinus syndrom, second degree atrioventricular block type Mobitz II and third degree AV block and in patients with combined ...
Costa, Roberto   +1 more
core   +2 more sources

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken   +4 more
wiley   +1 more source

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