Results 91 to 100 of about 14,756 (211)

Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons [PDF]

, 2018
Metabolite profling is an important tool that may better capture the multiple features of neurodegeneration. With the considerable parallels between mouse and human metabolism, the use of metabolomics in mouse models with neurodegenerative pathology ...
A Aguzzi, A Bitsch, A Brand, A Ciechanover, A Falkowska, A Schousboe, A Suraweera, A Ugun-Klusek, A Walter, AC Yu, AE Frakes, AM Brown, BA Holshouser, BL Finlay, C Jaeger, CM Ellis, D Broadhurst, D Garfinkel, DS Dunlop, E Trushina, FJ Dennissen, G Kleiger, GE Meredith, GJ Patti, H Kawamata, H Wu, HDE Booth, I Carrero, I Saez, I Tkac, International Genomics of Alzheimer’s Disease, J Elkharaz, J Klein, J Lalande, J Lowe, J Marcinkiewicz, JB Clark, JR Moffett, JR Moffett, JT Greenamyre, JZ Tsien, K Brockmann, K Takayama, KE Burgin, KI Mosher, L Bedford, L Chang, M Castillo, M Jove, M Komatsu, M Malik, M Mayford, MC McKenna, MC Pardon, ME Murray, N Aytan, NT Glanville, O Beckonert, Q Zheng, RJ Maddock, RM Salek, TE Bates, TE Bates, TM Ebbels, TR Jay, TR Sampson, U Sonnewald, V Govindaraju, Y Su   +68 more
core   +4 more sources

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

MRS study of meningeal hemangiopericytoma and edema: A comparison with meningothelial meningioma [PDF]

, 2012
Intracranial hemangiopericytomas (HPCs) are rare tumors and their radiological appearance resembles that of meningiomas, especially meningothelial meningiomas.
Bacci, A., Bonora, S., Mucci, Adele, Righi, V., Schenetti, Luisa, Tugnoli, V.   +5 more
core   +1 more source

Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2479-2488, May 2026.
ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley   +1 more source

Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

Neurobiology of Disease, 2001
There is substantial evidence for bioenergetic defects in Huntington's disease (HD). Creatine administration increases brain phosphocreatine levels and it stabilizes the mitochondrial permeability transition.
Ole A. Andreassen, Alpaslan Dedeoglu, Robert J. Ferrante, Bruce G. Jenkins, Kimberly L. Ferrante, Melissa Thomas, Avi Friedlich, Susan E. Browne, Gabriele Schilling, David R. Borchelt, Steven M. Hersch, Christopher A. Ross, M.Flint Beal   +12 more
doaj   +1 more source

Inter‐Individual Differences in T1, T2, and Proton Density Using Quantitative Synthetic Imaging for 1H‐MRS Quantification

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2489-2499, May 2026.
ABSTRACT Purpose Metabolite concentrations can be determined from proton magnetic resonance spectroscopy (1H‐MRS) data using water as an internal reference. This calculation requires tissue‐specific water T1 and T2 relaxation constants and proton density (PD).
Samantha A. Leech, Sarah L. Manske, Paul G. Mullins, Tiffany K. Bell, Ashley D. Harris   +4 more
wiley   +1 more source

Canavan disease [PDF]

, 2005
Canavan disease (CD) is an autosomal recessive disorder, characterized by spongiform degeneration of the white matter of the brain. Aspartoacylase (ASPA) hydrolyses N-acetylaspartic acid to aspartate and acetate.
Surendran, Sankar
core  

Reduced Whole‐Brain Network Segregation and Dorsal Anterior‐Cingulate Cortex Neurochemical Alterations in Chronic Smokers

Brain and Behavior, Volume 16, Issue 4, April 2026.
Chronic smokers exhibited less segregated brain networks and shifts in centrality from executive to reward‐related regions. Additional spectroscopy measures revealed lower tNAA in the dorsal anterior cingulate cortex, highlighting network‐level and neurochemical alterations that may underlie smoking‐related vulnerability.
Humberto Monsivais, Francesco Versace, Max Wintermark, Brian A. Taylor   +3 more
wiley   +1 more source

Cingulate metabolites during pain and morphine treatment as assessed by magnetic resonance spectroscopy

Journal of Pain Research, 2014
Tine Maria Hansen,1 Anne Estrup Olesen,2 Carsten Wiberg Simonsen,1 Asbjørn Mohr Drewes,2,3 Jens Brøndum Frøkjær11Mech-Sense, Department of Radiology, 2Mech-Sense, Department of Gastroenterology, 3Center for Sensory-Motor ...
Hansen TM, Olesen AE, Simonsen CW, Drewes AM, Frøkjær JB   +4 more
doaj  

Prenatal (1–3)IGF‐1 Treatment Is Ineffective and Behaviorally Detrimental in a Rat Model of Cortical Malformation

Brain and Behavior, Volume 16, Issue 4, April 2026.
Prenatal MAM exposure induces cortical malformation with reduced brain size evident on fetal MRI (E19). (1–3)IGF‐1 treatment showed no rescue at P15 and was associated with long‐term behavioral impairment, including reduced novelty preference and increased freezing behavior. Abstract Background Malformations of cortical development (MCD), a major cause
Minyoung Lee, Eun‐Jin Kim, Mi‐Sun Yum   +2 more
wiley   +1 more source