Results 111 to 120 of about 14,756 (211)

Proton Magnetic Resonance Spectroscopic Evidence of Glial Effects of Cumulative Lead Exposure in the Adult Human Hippocampus [PDF]

, 2011
Background: Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans.
Hu, Howard, Lenkinski, Robert E., Sparrow, David, Weisskopf, Marc G., Wright, Robert O.   +4 more
core   +1 more source

N-acetylaspartic acid monitors oxidative stress

, 2011
EXCLI Journal ; Vol.
openaire   +2 more sources

Selected Brain Metabolites and Mitochondrial DNA Copy Number as Potential Markers of Ongoing Neurodegeneration in Patients with Wolfram Syndrome

Metabolites
Background: Wolfram syndrome (WFS) is a rare neurodegenerative disease that is genetically determined and inherited in an autosomal recessive manner.
Ewa Zmysłowska-Polakowska, Tomasz Płoszaj, Sebastian Skoczylas, Julia Grzybowska-Adamowicz, Dobromiła Barańska, Katarzyna Matera, Aleksandra Palatyńska-Ulatowska, Wojciech Młynarski, Agnieszka Zmysłowska, Michal Ciborowski   +9 more
doaj   +1 more source

Hippocampal region metabolites and cognitive impairment in patients with general paresis: based on 1H-proton magnetic resonance spectroscopy

Frontiers in Pharmacology
Background:This study utilizes Hydrogen proton magnetic resonance spectroscopy (1H-MRS) to investigate metabolite concentrations in the bilateral hippocampus of general paresis (GP) patients.Methods:A total of 80 GP patients and 57 normal controls (NCs ...
Xin Che, Xin Che, Xin Che, Tianyang Miao, Tianyang Miao, Tianyang Miao, Haishan Shi, Haishan Shi, Haishan Shi, Zezhi Li, Zezhi Li, Zezhi Li, Yuping Ning, Yuping Ning, Yuping Ning   +14 more
doaj   +1 more source

Neurochemical changes in the progression of Huntington's disease: A meta-analysis of in vivo 1H-MRS studies

Neurobiology of Disease
Proton magnetic resonance spectroscopy (1H-MRS) allows measuring specific brain metabolic alterations in Huntington's disease (HD), and these metabolite profiles may serve as non-invasive biomarkers associated with disease progression.
Yinghua Jing, Imis Dogan, Kathrin Reetz, Sandro Romanzetti   +3 more
doaj   +1 more source

The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients

Neuropsychiatric Disease and Treatment, 2016
Ömer Başay,1 Burge Kabukcu Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Ahmet Buber,1 Senay Gorucu Yilmaz,3 Yılmaz Kıroğlu,4 Mehmet Emin Erdal,5 Hasan Herken2 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University,
Başay, Kabukçu Başay B, Alacam H, Öztürk, Büber A, Yilmaz SG, Kıroğlu Y, Erdal ME, Herken H   +8 more
doaj  

Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. [PDF]

, 2019
Age and Alzheimer's disease (AD) share some common features such as cognitive impairments, memory loss, metabolic disturbances, bioenergetic deficits, and inflammation.
Brewer, Gregory J, Dong, Yue
core  

NMR metabolomics reveals metabolic alterations in a novel mouse model of neurodegeneration

Frontiers in Neuroscience
IntroductionThe relationship between brain metabolism and neurodegenerative diseases is poorly understood. To investigate the pathophysiology of neurodegeneration, we used decrepit (dcr) mice, a mouse model with a mutation in a mitochondrial associated ...
Grace V. Mercer, Haley Adams, Drew P. Locke, Sophie Kiefte, Nikita Harvey, Rachel Coffey, Céline M. Schneider, Lindsay S. Cahill, Lindsay S. Cahill   +8 more
doaj   +1 more source

Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism. [PDF]

Prog Neurobiol, 2023
Lotun A, Li D, Xu H, Su Q, Tuncer S, Sanmiguel J, Mooney M, Baer CE, Ulbrich R, Eyles SJ, Strittmatter L, Hayward LJ, Gessler DJ, Gao G.   +13 more
europepmc   +1 more source

Associations between N-Acetylaspartate and white matter integrity in individuals with schizophrenia and unaffected relatives. [PDF]

Psychiatry Res Neuroimaging, 2023
Roberts D, Rösler L, Wijnen JP, Thakkar KN.   +3 more
europepmc   +1 more source