Results 161 to 170 of about 14,756 (211)
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N-Acetylaspartate and epilepsy
Magnetic Resonance Imaging, 1995Proton magnetic resonance spectra include signals from N-acetylaspartate, creatine + phosphocreatine, and choline-containing compounds. Abnormalities in these signals can be used in the assessment of patients with intractable epilepsy. In particular, they provide a means of identifying metabolic abnormalities within the temporal lobes, detecting ...
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N -Acetylaspartate in neuropsychiatric disorders
Progress in Neurobiology, 1995N-Acetyl aspartate (NAA) is the second most abundant amino acid in the human brain. NAA is synthesized by L-aspartate N-acetyl transferase or by cleavage from N-acetyl aspartyl glutamate by N-acylated alpha-linked L-amino dipeptidase (NAALADase); and it is catabolized to acetate and aspartate by N-acetyl aspartate amino hydrolase (amino acylase II ...
G, Tsai, J T, Coyle
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N-acetylaspartic acid in G-actin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1966Abstract A ninhydrin-negative peptide fraction obtained from pronase digestion of G-actin was isolated on a Dowex-50 X-2 (H + ) column. Analysis of this fraction by gas chromatography showed that most of the acetyl content of the original actin was recovered.
E, Gaetjens, M, Bárány
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N-Acetylaspartate as a reservoir for glutamate
Medical Hypotheses, 2006N-acetylaspartate (NAA) is an intermediary metabolite that is found in relatively high concentrations in the human brain. More specifically, NAA is so concentrated in the neurons that it generates one of the most visible peaks in nuclear magnetic resonance (NMR) spectra, thus allowing NAA to serve as "a neuronal marker".
Joseph F, Clark +6 more
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Decreased brain N-acetylaspartate in Huntington's disease
Brain Research, 1992The concentration of N-acetylaspartic acid (NAA) was measured in perchloric acid extracts of postmortem brain tissue obtained from patients with Huntington's disease and from control subjects. The material in the desalted extracts was resolved on an ion exclusion column and the content of NAA was determined by subsequent fluorometric quantitation of ...
D S, Dunlop, D M, Mc Hale, A, Lajtha
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Localisation of N-acetylaspartate in oligodendrocytes/myelin
Brain Structure and Function, 2013The role of N-acetylaspartate in the brain is unclear. Here we used specific antibodies against N-acetylaspartate and immunocytochemistry of carbodiimide-fixed adult rodent brain to show that, besides staining of neuronal cell bodies in the grey matter, N-acetylaspartate labelling was present in oligodendrocytes/myelin in white matter tracts ...
Kaja, Nordengen +4 more
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The accuracy of whole brain N-acetylaspartate quantification
Magnetic Resonance Imaging, 2000A non-localizing pulse sequence to quantify the total amount of N-acetylaspartate (NAA) in the whole brain (WBNAA) was introduced recently [Magn. Reson. Med. 40, 684-689 (1998)]. However, it is known that regional magnetic field inhomogeneities, deltaB0s, arising from susceptibility differences at tissue interfaces, shift and broaden local resonances ...
O, Gonen, R I, Grossman
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Immunohistochemical localization of N-acetylaspartate in rat brain
NeuroReport, 1991N-acetylaspartate (NAA) is one of the most prevalent compounds in the mammalian nervous system. As such, NAA largely contributes to the major peak on water-suppressed proton magnetic resonance spectra. Highly specific antibodies to NAA demonstrate that this compound is discretely localized in a substantial number of neurons throughout the extent of the
J R, Moffett +3 more
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An enzymatic fluorimetric assay for determination of N-acetylaspartate
Analytical Biochemistry, 2023N-acetylaspartate (NAA) is an abundant metabolite in the mammalian brain and a precursor of the neuropeptide N-acetylaspartylglutamate (NAAG). The physiological role of NAA is not fully understood and requires further studies. We here describe the development of a coupled enzymatic fluorimetric assay for the determination of NAA in biological samples ...
Ivonne Becker, Matthias Eckhardt
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