Results 21 to 30 of about 14,756 (211)

Neurometabolite alterations in traumatic brain injury and associations with chronic pain

Frontiers in Neuroscience, 2023
Traumatic brain injury (TBI) can lead to a variety of comorbidities, including chronic pain. Although brain tissue metabolite alterations have been extensively examined in several chronic pain populations, it has received less attention in people with ...
Linda E. Robayo, Linda E. Robayo, Varan Govind, Teddy Salan, Nicholas P. Cherup, Sulaiman Sheriff, Andrew A. Maudsley, Eva Widerström-Noga, Eva Widerström-Noga, Eva Widerström-Noga   +9 more
doaj   +1 more source

Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice [PDF]

, 2017
Background: Several clinical studies have suggested that N-acetylaspartate and N-acetylaspartylglutamate levels in the human brain are associated with various psychiatric disorders, including major depressive disorder. We have previously identified Shati/
Aoki, Ariyannur, Asberg, Atsumi Nitta, Banki, Becker, Bespalov, Bzdega, Chaki, Chopra, Engers, Franklin, Fukumoto, Furukawa-Hibi, Huang, Huezo-Diaz, Kato, Kazuyuki Sumi, Kequan Fu, Kessler, Krzyzosiak, Kupfer, Kyosuke Uno, Meyer, Michelsen, Miyamoto, Miyamoto, Miyazaki, Moffett, Moffett, Nadler, Nakamura, Nakatani, Neale, Neale, Niwa, Noriyuki Iegaki, Olszewski, Passani, Pehrson, Podkowa, Pollak Dorocic, Reynolds, Reynolds, Shin-ichi Muramatsu, Sota Azuma, Sumi, Takanashi, Tepper, Trivedi, Tsunoka, Wilkie, Yoshiaki Miyamoto, Yudai Ishikawa, Zuo   +54 more
core   +2 more sources

Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate

NeuroImage: Clinical, 2017
Multiple sclerosis (MS) is a pathologically complex CNS disease: inflammation, demyelination, and neuroaxonal degeneration occur concurrently and may depend on one another.
Emily Turner Wood, Ece Ercan, Pascal Sati, Irene C.M. Cortese, Itamar Ronen, Daniel S. Reich   +5 more
doaj   +1 more source

Magnetic resonance spectroscopy in Parkinson’s disease

Бюллетень сибирской медицины, 2020
Introduction. Modern neuroimaging methods allow to evaluate in vivo biochemical processes in the brain. Such methods include magnetic resonance spectroscopy (MRS) and positron emission tomography (PET). While PET is the “golden standard” in assessing the
Y. G. Khomenko, I. V. Miliukhina, E. V. Gracheva, G. V. Kataeva, A. A. Bogdan, E. A. Gromova, D. S. Susin   +6 more
doaj   +1 more source

Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies [PDF]

, 2016
Acknowledgements We thank Craig Lambert for his help in processing the MRS data. The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical ...
Blamire, A. M., Hayes, L., He, J., O'Brien, J. T., Su, L., Watson, R.   +5 more
core   +2 more sources

Frontal Metabolite Concentration Deficits in Opiate Dependence Relate to Substance Use, Cognition, and Self-Regulation. [PDF]

, 2016
ObjectiveProton magnetic resonance spectroscopy (1H MRS) in opiate dependence showed abnormalities in neuronal viability and glutamate concentration in the anterior cingulate cortex (ACC).
Abé, Christoph, Durazzo, Timothy C, Guydish, Joseph, Meyerhoff, Dieter J, Murray, Donna E, Schmidt, Thomas P   +5 more
core   +1 more source

N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users. [PDF]

, 2018
Background:Methamphetamine induces neuronal N-acetyl-aspartate synthesis in preclinical studies. In a preliminary human proton magnetic resonance spectroscopic imaging investigation, we also observed that N-acetyl-aspartate+N-acetyl-aspartyl-glutamate in
Alger, Jeffry R, Johnson, Maritza C, London, Edythe D, O'Neill, Joseph, Shen, Zhiwei, Tang, Jinsong   +5 more
core   +2 more sources

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]

, 2019
Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Gunter, Jeffrey L, Haley, Dana, Jones, David, Kantarci, Kejal, Knopman, David, Kraft, Ruth, Lapid, Maria, Lesnick, Timothy, Rademakers, Rosa, Rosen, Howie, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +22 more
core   +3 more sources

A Longitudinal H-MRS Study of the Anterior Cingulate Gyrus in Child and Adolescent Victims of Multiple Forms of Violence

Chronic Stress, 2018
Background The anterior cingulate gyrus is involved in the extinction of conditioned fear responses and is implicated in the pathophysiology of posttraumatic stress disorder.
Ana Carolina Coelho Milani, Bernd Foerster, Hugo Cogo-Moreira, Thiago Michel de Brito Farias, Francisco Salido, Henrique Carrete, Marcelo Feijo Mello, Andrea Parolin Jackowski   +7 more
doaj   +1 more source

Brain GABA and Glutamate Concentrations Following Chronic Gabapentin Administration: A Convenience Sample Studied During Early Abstinence From Alcohol. [PDF]

, 2018
Gabapentin (GBP), a GABA analog that may also affect glutamate (Glu) production, can normalize GABA and Glu tone during early abstinence from alcohol, effectively treating withdrawal symptoms and facilitating recovery.
Durazzo, Timothy C, Meyerhoff, Dieter J, Murray, Donna E, Pennington, David L   +3 more
core   +2 more sources