Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances
Mass Spectrometry Reviews, EarlyView.Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
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SÍNTESE DE N-GLICOSILSULFONAMIDAS DERIVADAS DE D-GLICOSE E N-ACETILGLICOSAMINA
Química Nova, 2015 Herein, we report the synthesis of β-N-glycosylsulfonamides derivatives of D-glucose and N-acetylglucosamine using conventional methods. We also describe a procedure that allows the preparation of these compounds in good yields without the anomerization ...
Lucas L. Franco +3 more
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Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid [PDF]
, 2018 The crystal structure of UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase; WbpP; EC 5.1.3.7), from the archaeal methanogen Methanobrevibacter ruminantium strain M1, was determined to a resolution of 1.65 Å. The structure, with a single monomer
Carbone, V +4 more
core
Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. [PDF]
, 2014 Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis. We tested anthracimycin against an expanded panel of Staphylococcus aureus strains in vitro and in vivo. All strains of S.
Cunningham, Mark L +12 more
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Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui +4 more
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Draft genome sequence of Bacillus thuringiensis strain BrMgv02-JM63, a chitinolytic bacterium isolated from oil-contaminated mangrove soil in Brazil. [PDF]
, 2014 Here, we report the draft genome sequence and the automatic annotation of Bacillus thuringiensis strain BrMgv02-JM63. This genome comprises a set of genes involved in the metabolism of chitin and N-acetylglucosamine utilization, thus suggesting the ...
ANDREOTE, F. D. +7 more
core
Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science
Mass Spectrometry Reviews, EarlyView.ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song +3 more
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Applied Microbiology and BiotechnologyThe persistence of commensal bacteria and administered probiotics in the human gut depends to some extent on their capacity to metabolize diet and host-derived glycans.
Víctor García-Telles +4 more
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Síntese de inibidores potenciais de hexosaminidases derivados de N-acetilglicosamina e D-glicose
Orbital: The Electronic Journal of Chemistry, 2012 We report herein the synthesis and characterization of N-acetylglucosamine and D-glucose derivates modified at C-1 for evaluation of antifungal activity as potential hexosaminidases inhibitors.
Lucas Lopardi Franco +3 more
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From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]
, 2009 Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine +4 more
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