Results 41 to 50 of about 14,921,471 (288)
Journal of Biological Chemistry, 2016 O-GlcNAcylation is a dynamic post-translational modification consisting of the addition of a single N-acetylglucosamine sugar to serine and threonine residues in proteins by the enzyme O-linked β-N-acetylglucosamine transferase (OGT), whereas the enzyme ...
R. M. de Queiroz +4 more
semanticscholar +1 more source
N-Acetylglucosamine Selectively Attenuates Neuroinflammation in a Mouse Model of Mitochondrial Dysfunction. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Mitochondrial dysfunction plays a central role in multiple neurodegenerative diseases, yet the temporal sequence of cellular events underlying neurodegeneration remains poorly defined. This study aimed to characterize the progression of neurodegeneration in a mouse model of fatal mitochondrial encephalopathy and to evaluate the therapeutic
Jiménez-Sánchez L +12 more
europepmc +2 more sources
Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]
, 2008 Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core +2 more sources
Journal of Biological Chemistry, 2015 Background: Bacillus subtilis is a model organism for analyzing bacterial biofilms, but the carbohydrate components are undescribed. Results: Genes in the epsHIJK locus needed for biofilm formation encode proteins synthesizing the conserved bacterial ...
D. Roux +10 more
semanticscholar +1 more source
Metabolic control of hyaluronan synthases [PDF]
, 2014 Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology ...
De Luca G. +4 more
core +1 more source
N-Acetylglucosamine-dependent nuclear import of neoglycoproteins [PDF]
Glycobiology, 1996 Nuclear proteins bearing O-linked N-acetylglucosaminyl residues are involved in nuclear transport and in transcriptional processes. However, the role of glycosylation remains to be determined. It was proposed that glycosylation could be involved in macromolecular complex formation or in nuclear targeting.
E, Duverger, A C, Roche, M, Monsigny
openaire +2 more sources
Selenium Protects Retinal Cells from Cisplatin-Induced Alterations in Carbohydrate Residues
Balkan Medical Journal, 2016 Background: Investigate alterations in the expression and localization of carbohydrate units in rat retinal cells exposed to cisplatin toxicity. Aims: The aim of the study was to evaluate putative protective effects of selenium on retinal cells ...
Dilek Akşit +8 more
doaj +1 more source
Journal of Biological Chemistry, 1984 Bovine milk galactosyltransferase has been used, in conjunction with UDP-[3H]galactose, as an impermeant probe for accessible GlcNAc residues on the surfaces of lymphocytes.
C R Torres, G. W. Hart
semanticscholar +1 more source
Substrate-Assisted Catalysis Unifies Two Families of Chitinolytic Enzymes [PDF]
, 1997 Hen egg-white lysozyme has long been the paradigm for enzymatic glycosyl hydrolysis with retention of configuration, with a protonated carboxylic acid and a deprotonated carboxylate participating in general acid-base catalysis.
Blake C. C. F. +28 more
core +3 more sources
Biosynthetic Enzymes of Tetrahydrolimipterin from Green Sulfur Bacterium Chlorobium Limicola
Pteridines, 1998 Based on the structure of limipterin (Cha, Pfleiderer, and Yim, Helv, Chim. Acta, 78: 600-614. 1995 the biosynthetic pathway for the newly identified pterin glycoside was investigated. It was demonstrated that tetrahydrolimipterin (H4 -limipterin) can be
Kang Dongmin, Kim Sangjoon, Yim Jeongbin
doaj +1 more source