Results 221 to 230 of about 1,001,057 (271)

In vivo evolutionary engineering of riboswitch with high-threshold for N-acetylneuraminic acid production.

Metabolic Engineering, 2020
Riboswitches with desired properties, such as sensitivity, threshold, dynamic range, is important for its application. However, the property change of a natural riboswitch is difficult due to the lack of the understanding of aptamer ligand binding ...
Qingxiao Pang, Hao Han, Xiaoqin Liu, Zhiguo Wang, Quanfeng Liang, Jin Hou, Q. Qi, Qian Wang   +7 more
semanticscholar   +1 more source

Configuration of N-acetylneuraminic Acid

Nature, 1958
RECENTLY, Comb and Roseman1 observed that N-acetyl-d-mannosamine and not N-acetyl-d-glucosamine was a substrate for the enzyme synthesizing N-acetylneuraminic acid (nanaldolase) isolated from Clostridium perfringens. These results seem to be in conflict with the synthesis of N-acetylneuramic acid from N-acetyl-d-glucosamine as reported by Corn-forth ...
J, BRUG, G B, PAERELS
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Synthesis of N-acetylneuraminic acid

Experientia, 1963
Die Synthese der N-Acetylneuraminsaure aus N-Acetylmannosamin und Oxalessigsaure und die Isolierung eines Zwischenproduktes, 2-Keto-3-deoxy-3-carboxy-5-N-acetylnonulosaminsaure wird beschrieben.
H, RINDERKNECHT, T, REBANE
openaire   +2 more sources

An efficient process for production of n-acetylneuraminic acid using n-acetylneuraminic acid aldolase

Enzyme and Microbial Technology, 1997
N-acetyl-D-neuraminic acid (Neu5Ac) aldolase (EC 4.1.3.3) has bee reported for synthesis of Neu5Ac,1-5 but there are no reports of processes which do not have significant drawbacks for large-scale operation. Here, Neu5Ac aldolase from an overexpressing recombinant strain of Escherichia coli has been used to develop an immobilized enzyme process for ...
M, Mahmoudian, D, Noble, C S, Drake, R F, Middleton, D S, Montgomery, J E, Piercey, D, Ramlakhan, M, Todd, M J, Dawson   +8 more
openaire   +2 more sources

N-Acetylneuraminic Acid: Neoglycoproteins and Pseudopolysaccharides

Journal of Carbohydrate Chemistry, 1987
Abstract A simplified procedure for the synthesis of acetochloroneuraminic acid is described starting from the methyl ester. N-acetyl neuraminic acid α-allyl glycoside was prepared in high yield using silver salicylate as catalyst. Reductive ozonolysis of the allyl group, followed by direct reductive ami nation to protein carriers, gave immunogenic ...
Roy, René, Laferrière, Craig A., Gamian, Andrzej, Jennings, Harold J.   +3 more
openaire   +2 more sources

Synthesis of a carbocyclic analogue of N-acetylneuraminic acid (pseudo-N-acetylneuraminic acid)

Journal of the Chemical Society, Chemical Communications, 1992
A carbocyclic analogue of N-acetylneuraminic acid was synthesized from the Diels–Alder endo-adduct of furan and acrylic acid, and its ammonium salt was subjected to biological assay.
Seiichiro Ogawa, Masaru Yoshikawa, Toshiaki Taki   +2 more
openaire   +1 more source

N-Acetylneuraminic acid storage disease

Human Genetics, 1985
Increased amounts of free sialic acid were found in body fluids, leukocytes, cultured fibroblasts, and liver tissue of a four-year-old boy with mental retardation, ataxia, and clinical and radiologic findings of a mild mucopolysaccharidosis. A diagnosis of Salla disease was made though in contrast to earlier reports, recurrent upper respiratory ...
J, Baumkötter, M, Cantz, K, Mendla, W, Baumann, H, Friebolin, J, Gehler, J, Spranger   +6 more
openaire   +2 more sources

Modular pathway engineering of key carbon‐precursor supply‐pathways for improved N‐acetylneuraminic acid production in Bacillus subtilis

Biotechnology and Bioengineering, 2018
N‐acetylneuraminic acid (NeuAc) is widely used as a nutraceutical for facilitating infant brain development, maintaining brain health, and enhancing immunity.
Xiaolong Zhang, Yanfeng Liu, Long Liu, Miao Wang, Jianghua Li, G. Du, Jian Chen   +6 more
semanticscholar   +1 more source

Glycosidation of N-acetylneuraminic acid

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1968
The synthesis of the methyl esters of 9-O-(β-D-glucopyranosyl)- and 9-O-(β-D-galaetopyranosyl)-N-acetylneuraminic acid is described.
A. Ya. Khorlin, I. M. Privalova
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Oral and Intraperitoneal Administration of N-Acetylneuraminic Acid: Effect on Rat Cerebral and Cerebellar N-Acetylneuraminic Acid

The Journal of Nutrition, 1986
Rat pups were administered N-acetylneuraminic acid (NANA) by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days, or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of
S E, Carlson, S G, House
openaire   +2 more sources