Results 231 to 240 of about 1,001,057 (271)
Some of the next articles are maybe not open access.
N-acetylneuraminic acid and hostile mucus infertility
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1987A total of 39 samples of hostile mucus, as defined by postcoital examination, were examined for N-acetylneuraminic acid (NANA) deficiency, as measured by the enzymatic addition of NANA, spermatozoal penetration and immobilization. Only 56.7% of the mucus samples were deficient in NANA and this did not correlate with spermatozoal penetration or ...
Polak B., Daunter B.
openaire +4 more sources
Acylation of N-acetylneuraminic acid
Chemistry of Natural Compounds, 1967The direct acylation of N-acetylneuraminic acid takes place ambiguously and leads to two reaction products: the acylated γ-lactone and the acylated derivative of the pyranose form of the acid.
A. Ya. Khorlin, I. M. Privalova
openaire +1 more source
A monoclonal antibody to free N-acetylneuraminic acid
Biochimica et Biophysica Acta (BBA) - General Subjects, 1990A monoclonal antibody (70-A) to free N-acetylneuraminic acid was obtained by immunizing mice with its synthetic beta-glycoside, sodium O-[(5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-2- nonulopyranosyl)onate]-(2----3)-1,2-di-O-tetradecyl-sn-glyce rol, followed by fusing the isolated spleen cells with mouse myeloma cells and cloning positive ...
A, Kawamura +7 more
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
Cultured skin fibroblasts from a patient suffering from generalized N-acetylneuraminic acid storage disease were found to accumulate large amounts (approx. 4.0 mumol/g fresh weight) of free N-acetylneuraminic acid in a lysosome-enriched subcellular fraction.
L W, Hancock, A L, Horwitz, G, Dawson
openaire +2 more sources
Cultured skin fibroblasts from a patient suffering from generalized N-acetylneuraminic acid storage disease were found to accumulate large amounts (approx. 4.0 mumol/g fresh weight) of free N-acetylneuraminic acid in a lysosome-enriched subcellular fraction.
L W, Hancock, A L, Horwitz, G, Dawson
openaire +2 more sources
Bioorganic & Medicinal Chemistry, 2000
Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase. Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.
Kiefel, MJ +4 more
openaire +3 more sources
Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase. Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.
Kiefel, MJ +4 more
openaire +3 more sources
The first synthesis of N-acetylneuraminic acid 1,7-lactone
Chemical Communications, 2008N -Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N -acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative ...
R. Colombo +3 more
openaire +3 more sources
Asymmetric synthesis of N-acetylneuraminic acid
Chemical Communications, 2000A highly diastereoselective synthesis of N-acetylneuraminic acid 1 has been completed by stereoselective functionalization of cis-olefin 6 and trans-olefin 10 via intramolecular phenylselenoamidation and osmylation, respectively.
Sung Ho Kang +3 more
openaire +1 more source
The benzhydryl ester of N-acetylneuraminic acid
Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1966Benzhydryl protection of the carboxy group of N-acetylneuraminic acid has been described for the first time.
A. Ya. Khorlin, I. M. Privalova
openaire +1 more source
An improved synthesis of n-acetylneuraminic acid
Carbohydrate Research, 1969Abstract The overall yield and stereoselectivity of the aldol condensation reactions of 2-acetamido-2-deoxy- D -glucose and 2-acetamido-2-deoxy- D -mannose with oxal-acetate at pH 10 are improved by the incorporation of borate ion in the reaction mixture. Borate ion inhibits the alkaline epimerisation of various 2-acylamino-2-deoxyaldoses.
M.J. How +3 more
openaire +1 more source
Enzymatic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-O-methyl-N-acetylneuraminic acid
Tetrahedron: Asymmetry, 1994Abstract 7-Deoxy- N -acetylneuraminic Acid and 7- O -methyl- N -acetylneuraminic acid were synthesized through the sialic acid aldolase-catalyzed aldol addition reactions of 4-deoxy- N -acetyl-D-mannosamine and 4- O -methyl- N -acetyl-D-mannosamine, respectively, with pyruvate. The obtained sialic acids will be used as probes for the investigation of
Randall L. Halcomb +2 more
openaire +1 more source