Results 21 to 30 of about 13,016,842 (92)

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

open access: yesNature, 2020
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon   +124 more
semanticscholar   +1 more source

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

open access: yesThe Lancet, 2016
Background Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to
Theo Christine Megha Ryan M Zulfiqar A Alexandria Austi Vos Allen Arora Barber Bhutta Brown Carter Casey C   +499 more
semanticscholar   +1 more source

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

open access: yesThe Lancet, 2021
Summary Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
O. Abani   +499 more
semanticscholar   +1 more source

Landscape of somatic mutations in 560 breast cancer whole genome sequences

open access: yesNature, 2016
We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable
S. Nik-Zainal   +87 more
semanticscholar   +1 more source

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

open access: yesNew England Journal of Medicine, 2020
Background World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with coronavirus disease 2019 (Covid-19 ...
H. Pan   +73 more
semanticscholar   +1 more source

Advanced capabilities for materials modelling with Quantum ESPRESSO [PDF]

open access: yesJournal of Physics: Condensed Matter, 2017
Quantum ESPRESSO is an integrated suite of open-source computer codes for quantum simulations of materials using state-of-the-art electronic-structure techniques, based on density-functional theory, density-functional perturbation theory, and many-body ...
P. Giannozzi   +49 more
semanticscholar   +1 more source

THE SEVENTH DATA RELEASE OF THE SLOAN DIGITAL SKY SURVEY [PDF]

open access: yes, 2008
This paper describes the Seventh Data Release of the Sloan Digital Sky Survey (SDSS), marking the completion of the original goals of the SDSS and the end of the phase known as SDSS-II. It includes 11,663 deg2 of imaging data, with most of the ∼2000 deg2
K. Abazajian   +203 more
semanticscholar   +1 more source

Mapping the human genetic architecture of COVID-19

open access: yesNature, 2021
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics
Mari E. K. Juha Rachel G. Benjamin M. Mark Andrea Gita Niemi Karjalainen Liao Neale Daly Ganna Pathak And   +499 more
semanticscholar   +1 more source

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

open access: yesLancet Neurology, 2019
Summary Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate.
Spencer L Alice Richard G Marlena S Wcliff Lydia R Nooshin James Theadom Ellenbogen Bannick Montjoy-Venning L   +374 more
semanticscholar   +1 more source

The Immune Landscape of Cancer.

open access: yesImmunity, 2018
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA.
V. Thorsson   +499 more
semanticscholar   +1 more source

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