Connected $(n,m)$-Point Functions of Diagonal $2$-BKP Tau-Functions, and Spin Double Hurwitz Numbers [PDF]
, 2022 Zhiyuan Wang, Chenglang Yang
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Regular n-valent n-connected nonHamiltonian non-n-edge-colorable graphs
Journal of Combinatorial Theory, Series B, 1973 For all \(n\geq 3\), except \(n=5,6,\) or 7 regular \(n\)-valent non-Hamiltonian non \(n\)-edge-colourable graphs are constructed by replacing edges of Petersen's graph by multiple edges, then replacing vertices with complete bipartite graphs. For \(n=5,6\), or 7, the same procedure gives graphs that are regular \(n\)-valent, Hamiltonian, and non \(n\)-
openaire +1 more source
Locally Connected Spiking Neural Networks for Unsupervised Feature\n Learning [PDF]
, 2019 Daniel J. Saunders +4 more
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A wild Cantor set in $E^n$ with simply connected complement [PDF]
, 1974 D. DeGryse, Richard L. Osborne
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Geometric criteria for $\\mathbb A^1$-connectedness and applications to\n norm varieties [PDF]
, 2021 Chetan Balwe, Amit Hogadi, Anand Sawant
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
An improvement on the upper bound of exponential sums connected to\n holomorphic cusp forms [PDF]
, 2010 Anne-Maria Ernvall-Hytönen
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