The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Detecting clinically relevant topological structures in multiplexed spatial proteomics using TopKAT. [PDF]
Patterns (N Y)Samorodnitsky S +6 more
europepmc +1 more source
On the genus of an n-connected graph [PDF]
Fundamenta Mathematicae, 1964 Harary, Frank, Kodama, Y.
openaire +1 more source
Initial Results from a Grid-Connected 2-Axis Solar Tracking PV System at 65°N in Piteå, Sweden
, 2012 Tobias Boström +3 more
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Remarks on a Scaling Theory of Spread of COVID-19 with an Application to the Case of Bulgaria. [PDF]
Entropy (Basel)Kartalov S, Vitanov NK.
europepmc +1 more source
A note on the connectedness locus of the families of polynomials Pc(z)=z n - cz n-j
, 2012 Carlos Arteaga, Alexandre Alonso Alves
openalex +1 more source
The largest strongly connected component in Wakeley et al's cyclical\n pedigree model [PDF]
, 2014 Jochen Blath +2 more
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Detecting faulty lithium-ion cells in large-scale parallel battery packs using current distributions. [PDF]
Commun EngLambert P +5 more
europepmc +1 more source