Results 161 to 170 of about 6,740 (213)

In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide

Drug Metabolism and Disposition, 2002
Oxidative metabolism of the insect repellent N,N-diethyl-m-toluamide (DEET) by pooled human liver microsomes (HLM), rat liver microsomes (RLM), and mouse liver microsomes (MLM) was investigated. DEET is metabolized by cytochromes P450 (P450s) leading to the production of a ring methyl oxidation product, N,N-diethyl-m-hydroxymethylbenzamide (BALC), and ...
Khawja A, Usmani, Randy L, Rose, Joyce A, Goldstein, Wesley G, Taylor, Alan A, Brimfield, Ernest, Hodgson   +5 more
openaire   +3 more sources

The Use of N, N-Diethyl-m-Toluamide to Enhance Dermal and Transdermal Delivery of Drugs

Journal of Pharmaceutical Sciences, 1982
A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Diethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model.
J J, Windheuser, J L, Haslam, L, Caldwell, R D, Shaffer   +3 more
openaire   +3 more sources

Adverse events associated with the use of insect repellents containing N,N-diethyl-m-toluamide (DEET)

Regulatory Toxicology and Pharmacology, 2010
DEET is the major component of most topically applied insect repellents used in the US. The DEET Registry is a post-marketing surveillance system to provide systematic and detailed information about medical events temporally associated with DEET use. From 1995 to 2001, 296 moderate and major severity cases were included in the DEET Registry.
T G, Osimitz, J V, Murphy, L A, Fell, B, Page   +3 more
openaire   +3 more sources

Biodegradation of the Insecticide N,N-Diethyl-m-Toluamide by Fungi: Identification and Toxicity of Metabolites

Archives of Environmental Contamination and Toxicology, 2005
Fungi (Cunninghamella elegans ATCC 9245, Mucor ramannianus R-56, Aspergillus niger VKMF-1119, and Phanerochaete chrysosporium BKMF-1767) were tested to elucidate the biologic fate of the topical insect repellent N,N-diethyl-m-toluamide (DEET). The elution profile obtained from analysis by high-pressure liquid chromatography equipped with a reverse ...
J, Seo, Y-G, Lee, S-D, Kim, C-J, Cha, J-H, Ahn, H-G, Hur   +5 more
openaire   +3 more sources

Decomposition of N, N-diethyl-m-toluamide by water plasma with mist generation

Journal of Environmental Chemical Engineering, 2022
Soon-Ho Kim, Manabu Tanaka, Myeong-Hoon LEE, Takayuki Watanabe   +3 more
openaire   +2 more sources

Kinetic and mechanistic investigation of photocatalytic degradation of the N,N-diethyl-m-toluamide

Chemical Engineering Journal, 2013
Abstract Analytical and electron paramagnetic resonance (EPR) spectroscopic methods were systematically used for the kinetic and mechanistic investigation of the photocatalytic degradation of N,N-diethyl-m-toluamide (DEET), in aqueous TiO2 suspensions under simulated solar light.
M. Antonopoulou, A. Giannakas, Y. Deligiannakis, I. Konstantinou   +3 more
openaire   +2 more sources

Fenvalerate/N,N-diethyl-m-toluamide (Deet) toxicosis in two cats

Journal of the American Veterinary Medical Association, 1990
Toxicosis attributable to fenvalerate and N,N-diethyl-m-toluamide (Deet) exposure was suspected in 2 cats. Clinical signs of toxicosis developed within 4 to 6 hours of dermal application of the pesticide. Clinical signs of toxicosis seen in both cats included hypersalivation, ataxia, and depression. In addition, seizures were seen in 1 cat.
D C, Dorman, W B, Buck, H L, Trammel, R D, Jones, V R, Beasley   +4 more
openaire   +2 more sources

INSECT REPELLANT INTERACTIONS: SUNSCREENS ENHANCE DEET (N,N-DIETHYL-M-TOLUAMIDE) ABSORPTION

Drug Metabolism and Disposition, 2004
Edward A. Ross, Kathleen A. Savage, Luke J. Utley, Ian R. Tebbett   +3 more
openaire   +2 more sources

Schistosomiasis prophylaxis in vivo using N,N-Diethyl-m-toluamide (DEET)

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2003
Topical N,N-Diethyl-m-toluamide (DEET) was studied as a schistosomiasis prophylactic in vivo for the use of individuals with limited exposure. Fifteen subjects, on a 3-week expedition to Lake Malawi in September 2001, applied 50% DEET to their skin after exposure to lake water. No subjects developed evidence of a new infection at 3-month follow-up.
F, Jackson, J F, Doherty, R H, Behrens
openaire   +2 more sources

Microencapsulation decreases the skin absorption of N,N-diethyl-m-toluamide (DEET)

Toxicology in Vitro, 2008
The insect repellent N,N-diethyl-3-methylbenzamide (DEET) is widely used and is generally regarded as safe when used according to label instructions. Yet many studies have shown it to be absorbed through the skin. The objective of this study was to determine whether the skin absorption rate of DEET could be decreased while maintaining an evaporation ...
Gerald B, Kasting, Varsha D, Bhatt, Tycho J, Speaker   +2 more
openaire   +2 more sources