Expulsion of nuclear DNA to the cytoplasm after viral entry: A mechanism for activation of the cGAS pathway. [PDF]
Romero N +6 more
europepmc +1 more source
Organoids: Current Applications and Future Directions
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng +14 more
wiley +1 more source
Spaces and sequences in the hippocampus: a homological perspective. [PDF]
Babichev A, Vashin V, Dabaghian Y.
europepmc +1 more source
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta +2 more
wiley +1 more source
WNetAlign: fast and accurate spectra alignment using truncated Wasserstein distance and network simplex. [PDF]
Król J +5 more
europepmc +1 more source
ABSTRACT In this work, we introduce and study the p$$ p $$‐α$$ \alpha $$‐closest‐center problem (pα$$ p\alpha $$CCP), which is a generalization of the p$$ p $$‐second‐center problem, a recently emerged variant of the classical (discrete) p‐center problem.
Elisabeth Gaar +2 more
wiley +1 more source
Phenotypic Diversity in Multiple Sclerosis Can Be Represented by Four Additive Symptom Modules. [PDF]
Hier DB, Srinivasula PY, Carrithers MD.
europepmc +1 more source
More than proteins for empty stomachs: Wild meat in the BaTonga food system
Abstract Our paper highlights the limitations of the framework used by many conservation‐focused programmes that incorporate food security objectives. This framework encourages the substitution of wild proteins with domestic proteins by promoting animal farming in communities located near conservation areas.
Muriel Figuié +5 more
wiley +1 more source
An Enhanced Black-Winged Kite Algorithm with Multiple Strategies for Global Optimization and Constrained Engineering Applications. [PDF]
Du C, Zhang J, Fang J.
europepmc +1 more source
LIPOTHERM: A Calibration Framework for GDGT Paleothermometry Based on Machine Learning
Abstract SST reconstruction from glycerol dialkyl glycerol tetraethers (GDGT) preserved in marine sediments is an important tool in quantitative paleoclimatology. These reconstructions require calibration frameworks that provide mapping between sediment GDGT data and temperature values.
Vikash Kumar +2 more
wiley +1 more source

