Results 121 to 130 of about 25,544 (130)

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Alcohol Dehydrogenase 4‐Mediated Retinol Metabolism Inhibits Hepatocellular Carcinoma Progression Through Inhibiting the Wnt/β‐Catenin Pathway

MedComm – Oncology, Volume 4, Issue 2, June 2025.
The downregulation of ADH4 expression induces hepatocyte apoptosis, thereby contributing to liver fibrosis and the initiation of hepatocellular carcinoma (HCC). Moreover, sustained suppression of ADH4 in HCC cells disrupts retinoic acid synthesis, leading to reduced expression of the Wnt/β‐catenin signaling inhibitor WIF‐1 via RARs/RXRs‐mediated ...
Jiaying Li, Mingshu Gao, Yanan Zhang, Dawen Liao, Feng Zhou, Zhaohui Zhang, Lele Ji, Yilin Zhao, Qichao Huang, Qian Bi, Nan Wang   +10 more
wiley   +1 more source

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages

Smart Medicine, Volume 4, Issue 2, June 2025.
This study reveals that polyamine metabolism significantly impacts thyroid carcinoma progression by modulating tumor‐associated macrophage phenotypes, influencing tumor growth and immune responses. ABSTRACT Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma ...
Haoran Ding, Lingling Xue, Shaoshi Zhu, Ziyu Wang, Huan Gui, Guang Zhang, Ning Tang, Haozhen Ren, Dayu Chen   +8 more
wiley   +1 more source

Breaking the Complexity of Cancer Using Computational Transcriptomic Network Biology

WIREs Computational Statistics, Volume 17, Issue 2, June 2025.
ABSTRACT While the landscapes of cancer mutations have been mostly clarified, in this study, we focused on the connective aggregates between mutations and phenotypes, named here as “gene transcriptomic networks,” aiming to survey computational network biology processes that have achieved significant results in cancer biology.
Heewon Park, Satoru Miyano
wiley   +1 more source

ATR Inhibition Synergizes With Alkylating PI Polyamide Targeting MYCN by Suppressing DNA Repair in MYCN‐Amplified Neuroblastoma

Cancer Science, Volume 116, Issue 6, Page 1691-1702, June 2025.
We found that among the DNA damage response inhibitors, ataxia telangiectasia and Rad3‐related (ATR) inhibitors synergized with CCC‐002 to suppress DNA repair‐related genes and induce apoptosis in MYCN‐amp neuroblastoma cells. These findings suggest that the combination of ATR inhibition and CCC‐002 is highly effective against MYCN‐amp neuroblastomas ...
Xiaoyi Lai, Hiroyuki Yoda, Yuming Qiao, Yuki Kida, Keizo Takenaga, Yoshinao Shinozaki, Nobuko Koshikawa, Atsushi Takatori   +7 more
wiley   +1 more source

Optical Probes for Cellular Imaging of G‐quadruplexes: Beyond Fluorescence Intensity Probes

Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.
DNA and RNA can fold into tetra‐stranded helical structures known as G‐quadruplexes (G4s). There is mounting evidence suggesting that these structures have important biological roles. In this minireview we discuss advances in the design of optical probes for the detection of G4s that offer intensity‐independent readouts that address limitations of ...
Jenna Robinson, Aatikah Majid, Marina K. Kuimova, Ramon Vilar   +3 more
wiley   +2 more sources

AMBRA1 Inhibits Non‐Small Cell Lung Cancer Progression Through miR‐1178/p53/CDK2‐Regulated Cell Cycle Arrest

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT AMBRA1 is associated with a variety of pathological processes in cancer cells, but may have different functions in different tumour microenvironments or genetic backgrounds. In this study, the function and regulatory mechanisms of AMBRA1 were explored in the progression of non‐small cell lung cancer (NSCLC).
Jing Feng, Shan Li, Laihua Li, Zhiqiang Du, Guangying Yang, Zhi Zhao, Xueke Fan, Na Wang, Zhigang Zhao   +8 more
wiley   +1 more source

OVOL1 Promotes Proliferation and Metastasis of Non‐Small Cell Lung Cancer by Regulating APOE‐Mediated Cholesterol Metabolism

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Non‐small cell lung cancer (NSCLC) is a highly lethal malignant tumour characterised by its resistance to treatment, often due to metabolic reprogramming. Despite this, the underlying mechanisms by which aberrant cholesterol metabolism influences the development and progression of NSCLC remain unclear.
Shoujie Feng, Li Zhang, Teng Sun, Lei Xu, Xiaoyu Quan, Guoqing Zhao, Hao Zhang   +6 more
wiley   +1 more source