Results 1 to 10 of about 85,046 (159)

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Nature, 2023
In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
T. Mulroney, Tuija Pöyry, J. C. Yam-Puc, Maria Rust, Robert F. Harvey, Lajos Kalmár, E. Horner, Lucy Booth, Alexander P Ferreira, M. Stoneley, Ritwick Sawarkar, A. Mentzer, Kathryn S. Lilley, C. M. Smales, T. von der Haar, L. Turtle, Susanna J . Dunachie, P. Klenerman, James E. D. Thaventhiran, A. Willis   +19 more
semanticscholar   +1 more source

Multi-Influenza HA Subtype Protection of Ferrets Vaccinated with an N1 COBRA-Based Neuraminidase

Viruses, 2023
The influenza neuraminidase (NA) is a promising target for next-generation vaccines. Protection induced by vaccination with the computationally optimized broadly reactive NA antigen (N1-I COBRA NA) was characterized in both influenza serologically naive ...
A. L. Skarlupka, Xiaojian Zhang, U. Blas-Machado, Spencer F. Sumner, T. Ross   +4 more
semanticscholar   +1 more source

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

ACS Central Science, 2021
The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history.
Kellie D. Nance, J. Meier
semanticscholar   +1 more source

Synthesis, Structure and Reactivity of Organoindium 1,2‐Benzenedithiolates and 2‐Amidobenzenethiolates

European Journal of Inorganic Chemistry, Volume 26, Issue 7, March 1, 2023., 2023
Organoindium compounds of redox‐active 1,2‐benezenedithiolate and 2‐amidobenzenethiolate ligands have been synthesized for assessment of their reactivity. Organoindium 3,4‐toluenedithiolate compounds undergo oxidation of the dithiolate ligand to produce oligomeric disulfides.
Glen G. Briand, Tanner George, Gregory A. MacNeil, Jason D. Masuda, Brian J. MacLean, Michael W. R. Mosher, Gregory M. Sandala, Padmapriya Srinivasan, Alexander H. Stockli, Rachel L. Vanderkloet, Charles J. Walsby   +10 more
wiley   +1 more source

Prognostic value of tumor-associated N1/N2 neutrophil plasticity in patients following radical resection of pancreas ductal adenocarcinoma

Journal for ImmunoTherapy of Cancer, 2022
Background As an integral part of the tumor microenvironment (TME), tumor-associated neutrophils play a crucial role in tumor development. The objective of this study was to investigate the plasticity of tumor-associated N1 and N2 neutrophils in the TME ...
Qiangda Chen, H. Yin, Siyao Liu, S. Shoucair, N. Ding, Yuan Ji, Jicheng Zhang, Dansong Wang, T. Kuang, Xue-feng Xu, Jun Yu, Wenchuan Wu, N. Pu, W. Lou   +13 more
semanticscholar   +1 more source

Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple‐negative breast cancers

Clinical and Translational Medicine, Volume 12, Issue 1, January 2022., 2022
Graphical Highlights TGF‐β1 stimulates PTX3 transcription by activating the transcription factor CEBPD in breast CAFs. The PTX3/CD44 interaction contributes to the metastasis/invasion and stemness of MDA‐MB‐231 via TWIST2, MMP2, RANKL and NANOG in response to AKT‐ and ERK1/2‐activated NF‐κB.
Yu‐Wei Hsiao, Jhih‐Ying Chi, Chien‐Feng Li, Lei‐Yi Chen, Yi‐Ting Chen, Hsin‐Yin Liang, Yu‐Chih Lo, Jhen‐Yi Hong, Chin‐Pin Chuu, Liang‐Yi Hung, Jyun‐Yi Du, Wen‐Chang Chang, Ju‐Ming Wang   +12 more
wiley   +1 more source

N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs

Scientific Reports, 2022
In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N1 ...
Tien-Hao Chen, V. Potapov, Nan Dai, J. L. Ong, Bijoyita Roy   +4 more
semanticscholar   +1 more source

N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology

Immunological Reviews, 2022
Research on tumor‐associated neutrophils (TAN) currently surges because of the well‐documented strong clinical relevance of tumor‐infiltrating neutrophils.
B. B. Antuamwine, Rebeka Bosnjakovic, Francisca Hofmann-Vega, Xi Wang, T. Theodosiou, I. Iliopoulos, S. Brandau   +6 more
semanticscholar   +1 more source

Neutrophil N1 and N2 Subsets and Their Possible Association with Periodontitis: A Scoping Review

International Journal of Molecular Sciences, 2022
Periodontitis is a chronic non-communicable disease caused by dysbiotic changes that affect the subgingival microbiota. During periodontitis, neutrophils play a central role in the initial recognition of bacteria, and their number increases with the ...
L. Sansores-España, S. Melgar-Rodríguez, R. Vernal, B. A. Carrillo-Ávila, V. Martínez-Aguilar, J. Díaz-Zúñiga   +5 more
semanticscholar   +1 more source

N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Nature Communications, 2021
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is characterized by high recurrence and heterogeneity, yet its mechanism is not well understood.
Yanying Wang, Jing Wang, Xiaoyu Li, Xushen Xiong, Jianyi Wang, Ziheng Zhou, Xiaoxiao Zhu, Yang Gu, D. Dominissini, Lei He, Yong Tian, C. Yi, Z. Fan   +12 more
semanticscholar   +1 more source