Results 151 to 159 of about 85,046 (159)

Adiponectin suppresses stiffness-dependent, profibrotic activation of lung fibroblasts.

Am J Physiol Lung Cell Mol Physiol
Nemeth J, Skronska-Wasek W, Keppler S, Schundner A, Groß A, Schoenberger T, Quast K, El Kasmi KC, Ruppert C, Günther A, Frick M.   +10 more
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Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.

Journal of Medicinal Chemistry, 2022
Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have been identified and show efficacy in various rodent pain models. (S)-1-((
Guanglin Luo, Ling Chen, W. Kostich, B. Hamman, Jason Allen, Amy E. Easton, C. Bourin, Michael Gulianello, J. Lippy, S. Nara, T. Maishal, K. Thiyagarajan, Prasadrao Jalagam, S. Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, S. Elavazhagan, M. Verma, M. L. Das, S. Wagh, Anand Balakrishnan, Benjamin M. Johnson, K. Santone, G. Thalody, R. Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, S. Putlur, Sarat Kumar Sarvasiddhi, G. Shankar, J. Louis, M. Ramarao, Charles M. Conway, Yu-Wen Li, R. Pieschl, Yuan Tian, Yang Hong, Jonathan L. Ditta, A. Mathur, Jianqing Li, Daniel J. Smith, J. Pawluczyk, Dawn Sun, S. Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan G. E. Wilson, S. Gopinathan, S. Wason, L. Bristow, C. Albright, J. Bronson, J. Macor, Carolyn D. Dzierba   +58 more
semanticscholar   +1 more source

Fiber bundle codes: breaking the n1/2 polylog(n) barrier for Quantum LDPC codes

Symposium on the Theory of Computing, 2020
We present a quantum LDPC code family that has distance Ω(N3/5/polylog(N)) and Θ(N3/5) logical qubits, where N is the code length. This is the first quantum LDPC code construction that achieves distance greater than N1/2 polylog(N).
M. Hastings, Jeongwan Haah, R. O'Donnell
semanticscholar   +1 more source

The Arm Neoverse N1 Platform: Building Blocks for the Next-Gen Cloud-to-Edge Infrastructure SoC

IEEE Micro, 2020
Recent years have seen an explosion of demand for high-performance, high-efficiency compute available at scale. This demand has skyrocketed with the move to the public cloud and 5G networking, where compute nodes must operate within strict latency ...
Andrea Pellegrini, Ashok Kumar Tummala, Jamshed Jalal, Mark David Werkheiser, Anitha Kona, Nigel Stephens, Magnus K. Bruce, Y. Ishii, Joseph Pusdesris, Abhishek Raja, Chris Abernathy, Jinson Koppanalil, Tushar P. Ringe   +12 more
semanticscholar   +1 more source

GR00T N1: An Open Foundation Model for Generalist Humanoid Robots

arXiv.org
General-purpose robots need a versatile body and an intelligent mind. Recent advancements in humanoid robots have shown great promise as a hardware platform for building generalist autonomy in the human world. A robot foundation model, trained on massive
Nvidia, Johan Bjorck, Fernando Castaneda, Nikita Cherniadev, Xingye Da, Runyu Ding, LinxiJimFan, Yu Fang, Dieter Fox, Fengyuan Hu, Spencer Huang, Joel Jang, Zhenyuan Jiang, Jan Kautz, Kaushil Kundalia, Lawrence Lao, Zhiqi Li, Zongyu Lin, Kevin Lin, Guilin Liu, Edith Llontop, Loic Magne, Ajay Mandlekar, Avnish Narayan, Soroush Nasiriany, Scott Reed, Y. Tan, Guanzhi Wang, Zu Wang, Jing Wang, Qi Wang, Jiannan Xiang, Yuqi Xie, Yinzhen Xu, Zhen-Teng Xu, Seonghyeon Ye, Zhiding Yu, Ao Zhang, Hao Zhang, Yizhou Zhao, Ruijie Zheng, Yuke Zhu   +41 more
semanticscholar   +1 more source

Visible-Light-Promoted Site-Selective N1-Alkylation of Benzotriazoles with α-Diazoacetates.

Organic Letters, 2020
A visible-light-promoted highly site-selective N1-alkylation of benzotriazoles with diazo compounds has been achieved under mild and metal-free conditions.
Jingya Yang, Jiaokui Duan, Ganggang Wang, Hongyan Zhou, Ben Ma, Chengqi Wu, Jianliang Xiao   +6 more
semanticscholar   +1 more source

8.3 A 3GHz ARM Neoverse N1 CPU in 7nm FinFET for Infrastructure Applications

IEEE International Solid-State Circuits Conference, 2020
The Neoverse family of Arm processors target a combination of high performance and compute density, enabling scalable computing platforms to power the internet infrastructure, from IoT gateways to datacentre servers.
R. Christy, S. Riches, Sujil Kottekkat, Prasanth Gopinath, Ketan Sawant, Anitha Kona, Rob Harrison   +6 more
semanticscholar   +1 more source

Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters

Drug Metabolism And Disposition, 2019
Endogenous substrates are emerging biomarkers for drug transporters, which serve as surrogate probes in drug-drug interaction (DDI) studies. In this study, the results of metabolome analysis using wild-type and Oct1/2 double knockout mice suggested that ...
T. Miyake, T. Mizuno, Issey Takehara, Tatsuki Mochizuki, M. Kimura, S. Matsuki, S. Irie, N. Watanabe, Y. Kato, I. Ieiri, K. Maeda, O. Ando, H. Kusuhara   +12 more
semanticscholar   +1 more source

The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.

Psychophysiology, 1987
R. Näätänen, T. Picton
semanticscholar   +1 more source