Results 51 to 60 of about 85,046 (159)

Evolution of a Reverse Transcriptase to Map N1-Methyladenosine in Human mRNA

Nature Methods, 2019
Chemical modifications to messenger RNA are increasingly recognized as a critical regulatory layer in the flow of genetic information, but quantitative tools to monitor RNA modifications in a whole-transcriptome and site-specific manner are lacking. Here
Huiqing Zhou, Simone Rauch, Qing Dai, X. Cui, Zijie Zhang, S. Nachtergaele, Caraline Sepich, Chuan He, B. Dickinson   +8 more
semanticscholar   +1 more source

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

Molecular Neurobiology, 2020
The structurally disordered N-terminal half of the prion protein (PrP C ) is constitutively released into the extracellular space by an endogenous proteolytic cleavage event.
B. Mohammadi, Luise Linsenmeier, M. Shafiq, B. Puig, G. Galliciotti, C. Giudici, M. Willem, Thomas Eden, F. Koch-Nolte, Yu-Hsuan Lin, J. Tatzelt, M. Glatzel, H. Altmeppen   +12 more
semanticscholar   +1 more source

Preoperative Staging by EBUS in cN0/N1 Lung Cancer

Journal of Bronchology & Interventional Pulmonology, 2019
Supplemental Digital Content is available in the text. Background: Performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for staging the radiologically normal mediastinum has been reported with inconsistent findings.
T. Leong, P. Loveland, A. Gorelik, L. Irving, Daniel P Steinfort   +4 more
semanticscholar   +1 more source

Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells

Scientific Reports, 2020
Microglia act as the protective immune cell of the brain. By surveying the tissue to identify and rectify problems, they function to maintain the health of brain cells.
James A. Carroll, B. Groveman, K. Williams, Roger A. Moore, Brent Race, C. Haigh   +5 more
semanticscholar   +1 more source

Identification of SRSF10 as a regulator of SMN2 ISS‐N1

Human Mutation, 2020
Understanding the splicing code can be challenging as several splicing factors bind to many splicing‐regulatory elements. The SMN1 and SMN2 silencer element ISS‐N1 is the target of the antisense oligonucleotide drug, Spinraza, which is the treatment ...
Sabrina B. Frederiksen, L. L. Holm, M. Larsen, T. K. Doktor, H. Andersen, M. Hastings, Y. Hua, A. Krainer, B. Andresen   +8 more
semanticscholar   +1 more source

Mulheres de cinema e a escrita da história do cinema de autoria feminina

Significação: Revista de Cultura Audiovisual, 2021
Nos últimos anos, no Brasil, o cinema dirigido por mulheres tem sido reconhecido em sua importância por meio de publicações como Mulheres de cinema, organizado por Karla Holanda.
Erika Amaral
doaj  

An Interview with Petra Slinkard Nancy B. Putnam Curator of Fashion and Textiles at the Peabody Essex Museum in Salem, Massachusetts

Fashion Studies, 2020
This article contains an interview with Petra Slinkard, the Nancy B. Putnam Curator of Fashion and Textiles at the Peabody Essex Museum in Salem, Massachusetts. Ms.
Marley Healy
doaj   +1 more source

Balance perturbation-evoked cortical N1 responses are larger when stepping and not influenced by motor planning.

Journal of Neurophysiology, 2020
The cortical N1 response to balance perturbation is observed in electroencephalography recordings simultaneous to automatic balance-correcting muscle activity.
Aiden M. Payne, L. Ting
semanticscholar   +1 more source

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Nucleic Acids Research, 2017
Certain chemical modifications confer increased stability and low immunogenicity to in vitro transcribed mRNAs, thereby facilitating expression of therapeutically important proteins.
Y. Svitkin, Y. Cheng, T. Chakraborty, Vladimir Presnyak, Matthias J John, N. Sonenberg   +5 more
semanticscholar   +1 more source

HELP: modelling the spectral energy distributions of Herschel detected galaxies in the ELAIS N1 field [PDF]

Astronomy & Astrophysics, 2018
Aims. The Herschel Extragalactic Legacy Project (HELP) focuses on the data from ESA’s Herschel mission, which covered over 1300 deg2 and is preparing to publish a multi-wavelength catalogue of millions of objects.

semanticscholar   +1 more source