Results 111 to 120 of about 372,622 (283)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source
MagnetismThis paper outlines a simple theoretical argument for the possibility of a quantum linear Voigt effect at low temperatures in certain media in the optical regime.
Neil Collings, Martin R. Parker
doaj +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
International Journal of Population Data ScienceBackground This project in one urban local authority in London (England) sought to assess the feasibility of generating locally-derived indices of overcrowding using data available to local councils on the population and their homes. We merged data at
Laura Scott +3 more
doaj +1 more source
Advanced Science, EarlyView.scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong +6 more
wiley +1 more source
The peculiarities of different types of chronic rhinitis in children and adolescents in Kazakhstan.
Iranian Journal of Public Health, 2013 The aim was to study the peculiarities of differential diagnosis, prevention and treatment of different forms of rhinitis in Kazakhstan children and adolescents.124 children and adolescents aged 1-17 years were randomly enrolled in our hospital based ...
Saule Zhumambayeva +7 more
doaj
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Respiratory Medicine Case ReportsCarbapenem-resistant Acinetobacter baumannii (CR-AB) is rarely found in community respiratory infections, and there are currently no reports of hemorrhagic bronchitis caused by its infection.
Zifang Li, Yu Sheng, Dongdong Huang
doaj +1 more source