Results 81 to 90 of about 20,182,615 (329)

Introduction: The Economics of Lordship in Late Medieval and Early Modern Europe

Jahrbuch für Wirtschaftsgeschichte
This special issue focuses on the economics of lordship in pre-industrial Europe. In the introduction, we start by briefly defining lordship, focusing on both the economic power lords had to demand rents from their tenants and the political power lords ...
Gibbs Spike, Skambraks Tanja
doaj   +1 more source

Innate lymphoid cells responding to IL-33 mediate airway-hyperreactivity independent of adaptive immunity

Journal of Allergy and Clinical Immunology, 2011
Background Asthma has been considered an immunological disease mediated by Th2 cells and adaptive immunity. However, clinical and experimental observations suggest that additional pathways may regulate asthma, particularly in non-allergic forms of asthma,
H. Y. Kim, Ya‐Jen Chang, S. Subramanian, Hyun-Hee Lee, L. Albacker, P. Matangkasombut, P. Savage, A. McKenzie, Dirk E. Smith, J. Rottman, R. DeKruyff, D. Umetsu   +11 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Statesman V. 51., n. 33

, 2008
v. : ill.; 32 cm (original analog pub.)Archived web contentThe digital publication of the Stony Brook Statesman was made possible through a grant from the Stony Brook Alumni ...
Stony Brook University Statesman
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Mortality Impact of Cholera in Germany

Jahrbuch für Wirtschaftsgeschichte
This paper presents the first comprehensive quantitative account of epidemic cholera in 19th-century Germany. Using a new dataset based on archival sources, it documents nearly half a million cholera deaths, along with outbreak timing and population at ...
Kappner Kalle
doaj   +1 more source

IL-33 induces protective effects in adipose tissue inflammation during obesity in mice

Circulation Research, 2010
Rationale: Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue ...
A. Miller, D. Asquith, A. Hueber, L. A. Anderson, W. M. Holmes, A. McKenzie, Damo Xu, N. Sattar, Iain B. McInnes, Fooyew Liew   +9 more
semanticscholar   +1 more source

Statesman, V. 33, n. 06

, 1989
v. : ill.; 32 cm (original analog pub.)Archived web contentThe digital publication of the Stony Brook Statesman was made possible through the kind support of The Stony Brook Alumni ...
Stony Brook University Statesman
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source