Results 91 to 100 of about 2,965,078 (287)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Estudio de gastos en insumos de mantenimiento correctivo de las cuñas tractoras en empresa de transporte. // An study about consumable parts of corrective maintenance costs of the tractive vehicles of the Transportation Filial of Almacenes Universales Ent

Ingeniería Mecánica, 2008
Las cuñas tractoras son vehículos de transporte utilizados en Cuba bajo intensas condiciones de explotación, con un sistemade mantenimiento preventivo, que teóricamente simultanea alta disponibilidad técnica a gastos aceptables.
B. Rigol Cardona, D. Peña Escobio, C. Batista Rodríguez   +2 more
doaj  

Investment and Saving Opportunities for Different Socio-Economic Groups in Medieval and Early Modern Europe

Jahrbuch für Wirtschaftsgeschichte
This special issue focuses on the financial behaviour of different participants in European medieval and early modern financial markets. It extends our knowledge of the financial strategies employed by households, merchants, charities, city governments ...
Nicolussi-Köhler Stephan, Conti Marco, Wandschneider Kirsten   +2 more
doaj   +1 more source

Statesman V. 53, n. 11

, 2009
v. : ill.; 32 cm (original analog pub.)Archived web contentThe digital publication of the Stony Brook Statesman was made possible through a grant from the Stony Brook Alumni ...
Stony Brook University Statesman
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

El RCVV: Un enfoque diferente en el diagnóstico técnico. // RCVV: A different approach to the Technical Diagnostic.

Ingeniería Mecánica, 2008
En el trabajo se presenta una nueva herramienta para ser utilizada en el diagnóstico técnico general de las máquinas. Elmétodo de Rapidez de Cambio del Valor de la Variable (RCVV), que cuantifica el síntoma de diagnóstico analizado,permite valorar ...
C. Batista Rodríguez, R. Urquiza Salgado   +1 more
doaj  

Credit for the Poor, Investments for the Rich? Different Strategies for Investing and Saving Money in Medieval Tirol

Jahrbuch für Wirtschaftsgeschichte
This paper provides an overview of the various financial resources that existed in medieval Tirol to meet financial needs, using notary registers and court records from the 14th century as sources.
Nicolussi-Köhler Stephan
doaj   +1 more source

Statesman V. 53, n. 23

, 2009
v. : ill.; 32 cm (original analog pub.)Archived web contentThe digital publication of the Stony Brook Statesman was made possible through a grant from the Stony Brook Alumni ...
Stony Brook University Statesman
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Manorial Plunder: Serfdom and Material Culture in Fifteenth-Century England

Jahrbuch für Wirtschaftsgeschichte
Heriot was a due paid by manorial tenants to their lords when they died, traditionally in the form of their best beast. Unlike other customary dues associated with serfdom that gradually disappeared from manorial courts in the later 14th and 15th ...
Johnson Tom
doaj   +1 more source