Results 31 to 40 of about 1,633,062 (199)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Baltic Timber Trade and the Port of Riga: Economic Empowerment of Middlemen and New Entrepreneurs in Imperial Russia’s Western Provinces (1860s to 1914)

open access: yesJahrbuch für Wirtschaftsgeschichte
The article discusses the advancement of timber traders and former middlemen in Riga’s timber trade during the second half of the 19th and early 20th century.
Wezel Katja
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Identification of trip generators using remote sensing and geographic information system

open access: yesTransportation Research Interdisciplinary Perspectives, 2019
The traditional methods of building and updating databases for transport analysis that address origin/destination (O/D) data collection, such as surveys and traffic counting, are generally manual, costly and time-consuming.
Cláudia A. Soares Machado   +1 more
doaj   +1 more source

Effect of Varying Amine Functionalities on CO2 Capture of Carboxylated Graphene Oxide-Based Cryogels

open access: yesNanomaterials, 2020
Graphene cryogels synthesis is reported by amine modification of carboxylated graphene oxide via aqueous carbodiimide chemistry. The effect of the amine type on the formation of the cryogels and their properties is presented.
Alina I. Pruna   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors: A Prospective, Randomized, Controlled Trial

open access: yesJournal of Ophthalmology, 2015
Purpose. To assess the efficacy and safety of corneal transplantation using corneas from foreign donors. Methods. One hundred and eight patients needing therapeutic penetrating keratoplasty were randomly divided into 2 groups (54 cases/group): foreign ...
Yingxin Chen   +6 more
doaj   +1 more source

Causative fungi and treatment outcome of dematiaceous fungal keratitis in North India

open access: yesIndian Journal of Ophthalmology, 2019
Purpose: The aim of the study is to identify risk factors, clinical characteristics, causative fungi, and treatment outcome of dematiaceous fungal keratitis in North India.
Ajit Kumar   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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