Results 101 to 110 of about 15,890,551 (242)

A Quasi-Stationary Twisted Disk Formed as a Result of a Tidal Disruption Event

Open Astronomy, 2016
In this note we briefly review the main results of our recent study of the formation of misaligned accretion disks after the tidal disruption of stars by rotating supermassive black holes.
Xiang-Gruess M., Ivanov P. B., Papaloizou J. C. B.   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A pilot image-based analysis of changes in pigment epithelial detachment composition in neovascular age-related macular degeneration

Indian Journal of Ophthalmology. Case Reports
We report changes in pigment epithelial detachment composition indices (PEDCI), derived using an automated algorithm, in six eyes with neovascular age-related macular degeneration (nAMD) through 84 months.
Sumit Randhir Singh, Stavan V. Shah, Abrahim Ahmed, Jordyn Vannavong, Hamza Sulharia, Rodney Fong, Cecilia Romero, Adam Wadsworth, Greggory Gahn, Arshad M. Khanani, Jay Chhablani   +10 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Ato n. 384/CSJT.GP.SG.SETIC.CGGOV, de 29 de dezembro de 2017

, 2017
Prorroga o prazo de atuação do grupo de trabalho instituído pelo Ato n. 84/CSJT.GP.SG.SETIC.CGGOV, de 11 de abril de 2017, destinado a conduzir as ações necessárias ao planejamento e eventual realização de processo licitatório para modernização e ...
Conselho Superior da Justiça do Trabalho (Brasil) (CSJT)
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Multivariable predictors of depressive symptoms (N = 84).

, 2014
I2 = 47.8% (95% CI 32.6 to 59.6).*Compared with the reference category, ad hoc supervision.Multivariable predictors of depressive symptoms (N = 84).
Joanna L. Hudson (636026), Peter Bower (52501), Karina Lovell (52502), Waquas Waheed (489211), Janine Archer (636027), Peter A. Coventry (399626), David A. Richards (337577), Simon Gilbody (52503), Chris Dickens (11503), Linda Gask (52505), Evangelos Kontopantelis (437866)   +10 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source