Results 41 to 50 of about 1,422,642 (242)
Financing Poor Relief in the Small Lower Rhine Town of Kalkar in the Late Middle Ages
Managing the poor’s funds in the Middle Ages was a great responsibility and a rather complex task that relied on the involvement and contributions of numerous persons, not least on the voluntary work of well-educated men.
Gussone Monika
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Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
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The connection between public spending and the ambitions of urban elites is a common topic in the historiography of the late Middle Ages. However, it is still unclear how city finances and private capital interacted before the use of sophisticated ...
Severgnini Carlo Ludovico
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The immortal strand hypothesis: still non-randomly segregating opinions
Cairns first suggested a mechanism for protecting the genomes of stem cells (SCs) from replicative errors some 40 years ago when he proposed the immortal strand hypothesis, which argued for the inheritance of a so-called immortal strand by an SC ...
Wakeman Jane A. +3 more
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Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
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The article discusses the advancement of timber traders and former middlemen in Riga’s timber trade during the second half of the 19th and early 20th century.
Wezel Katja
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Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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Introduction: The Economics of Lordship in Late Medieval and Early Modern Europe
This special issue focuses on the economics of lordship in pre-industrial Europe. In the introduction, we start by briefly defining lordship, focusing on both the economic power lords had to demand rents from their tenants and the political power lords ...
Gibbs Spike, Skambraks Tanja
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The aim of the topographic normalization of remotely sensed imagery is to reduce reflectance variability caused by steep terrain and thus improve further processing of images.
René Vázquez-Jiménez +4 more
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