Results 161 to 170 of about 326,728 (258)

APE1 may influence CD4+ naïve T cells on recurrence free survival in early stage NSCLC. [PDF]

BMC Cancer, 2021
Li Y, Zhao X, Xiao H, Yang B, Liu J, Rao W, Dai X, Li M, Dai N, Yang Y, Wang D.   +10 more
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Correction: IL-6 is one of the key factors in the formation of gut tissue resident memory T cells from Naïve T cells. [PDF]

PLoS Pathog
Kim HG, Chan A, Vimonpatranon S, Girard A, Jiang A, Wertz S, Hwang IY, Kehrl JH, Schmeisser H, Seemiller MM, Lusso P, Huang D, Wei D, Goes LR, Soares M, Martinelli E, Arthos J, Cicala C.   +17 more
europepmc   +1 more source

CD4⁺ regulatory and naïve T cells specific for factor VIII stand vis-à-vis to balance the immune response in healthy individuals. [PDF]

EJHaem, 2021
Schmidt A, Orlowski A, Salzmann-Manrique E, Königs C.   +3 more
europepmc   +1 more source

Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

, 2019
The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3.
Costantino Pitzalis (23531), Ana Cardus Figueras (16272920), Robert Andrews (30281), Nigel M Williams (12556939), Gareth W Jones (10223729), Myles J Lewis (16272929), Barbara Szomolay (5234141), Michael J Townsend (8665146), Philip R Taylor (8573847), Tony Tiganis (166257), Christopher Pepper (4467913), Jason P Twohig (16272917), David G Hill (10223711), David Millrine (16272932), Jasmine Li (4424320), Xiao Liu (65413), Simon A Jones (14865979), Alicia Derrac Soria (16272926), Benjamin C Cossins (16272923), Florian Wiede (166231), Javier Uceda Fernandez (16272935)   +20 more
core  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

IL-6 is one of the key factors in the formation of gut tissue resident memory T cells from Naïve T cells. [PDF]

PLoS Pathog
Kim HG, Chan A, Vimopatranon S, Girard A, Jiang A, Wertz S, Hwang IY, Kehrl JH, Schmeisser H, Seemiller MM, Lusso P, Huang D, Wei D, Goes LR, Soares M, Martinelli E, Arthos J, Cicala C.   +17 more
europepmc   +1 more source

Transcriptomic Analysis of the Effect of GAT-2 Deficiency on Differentiation of Mice Naïve T Cells Into Th1 Cells In Vitro. [PDF]

Front Immunol, 2021
Ding X, Chang Y, Wang S, Yan D, Yao J, Zhu G.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Involvement of naïve T cells in the pathogenesis of osimertinib-induced pneumonitis. [PDF]

Sci Rep
Ando H, Tsubouchi K, Yanagihara T, Hata K, Eto D, Suzuki K, Hamada N, Okamoto I.   +7 more
europepmc   +1 more source