Results 11 to 20 of about 64,649 (121)

Infarcts in a New Territory: Insights From the ESCAPE-NA1 Trial

Stroke, 2023
Background: Infarct in a new territory (INT) is a known complication of endovascular stroke therapy. We assessed the incidence of INT, outcomes after INT, and the impact of concurrent treatments with intravenous thrombolysis and nerinetide. Methods: Data
Nishita Singh, P. Cimflova, J. Ospel, N. Kashani, M. Marko, A. Mayank, R. Nogueira, R. McTaggart, A. Demchuk, A. Poppe, J. Rempel, Thalia Shoshana Field, D. Dowlatshahi, Brian van Adel, R. Swartz, R. Shah, E. Sauvageau, V. Puetz, F. Silver, B. Campbell, R. Chapot, M. Tymianski, M. Goyal, M. Almekhlafi, Michael D. Hill   +24 more
semanticscholar   +1 more source

CT Perfusion Does Not Modify the Effect of Reperfusion in Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment in the ESCAPE-NA1 Trial

American Journal of Neuroradiology, 2023
Various CTP metrics are used as biomarkers of ischemia and clinical outcomes in some patients undergoing EVT. This post hoc analysis of the Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) trial ...
N. Rex, R. McDonough, J. Ospel, N. Kashani, A. Sehgal, J. Fladt, R. McTaggart, Ricardo P Nogueira, B. Menon, A. Demchuk, M. Tymianski, M. Hill, M. Goyal   +12 more
semanticscholar   +1 more source

NADP+ or CO2 reduction by frhAGB-encoded hydrogenase through interaction with formate dehydrogenase 3 in the hyperthermophilic archaeon Thermococcus onnurineus NA1

Applied and Environmental Microbiology, 2023
It has been reported that the frhAGB-encoded hydrogenase from Thermococcus onnurineus NA1 is homologous to the F420-reducing hydrogenase from methanogens and can reduce thioredoxin reductase (TrxR) via direct electron transfer from H2 oxidation.
Ji-in Yang, Hae-Chang Jung, Hyun-Myung Oh, Bo Gyoung Choi, H. Lee, S. Kang   +5 more
semanticscholar   +1 more source

Predicting outcome in acute stroke with large vessel occlusion—application and validation of MR PREDICTS in the ESCAPE-NA1 population

Interventional Neuroradiology, 2023
Background Predicting outcome after endovascular treatment for acute ischemic stroke is challenging. We aim to investigate differences between predicted and observed outcomes in patients with acute ischemic stroke treated with endovascular treatment and ...
M. Marko, M. Goyal, J. Ospel, Nishita Singh, E. Venema, Raul G. Nogueira, A. Demchuk, R. McTaggart, Alexandre Y. Poppe, B. Menon, C. Zerna, Maxim J. H. L. Mulder, D. Dippel, H. Lingsma, B. Roozenbeek, M. Tymianski, M. D. Hill   +16 more
semanticscholar   +1 more source

A Novel NADP-Dependent Formate Dehydrogenase From the Hyperthermophilic Archaeon Thermococcus onnurineus NA1

Frontiers in Microbiology, 2022
The genome of the hyperthermophilic archaeon Thermococcus onnurineus NA1 contains three copies of the formate dehydrogenase (FDH) gene, fdh1, fdh2, and fdh3.
Ji-In Yang, S. Lee, J. Ryu, H. Lee, S. Kang   +4 more
semanticscholar   +1 more source

Dielectric Properties of Colossal-Dielectric-Constant Na1/2La1/2Cu3Ti4O12 Ceramics Prepared by Spark Plasma Sintering

Molecules, 2022
In the current study, we report on the dielectric behavior of colossal-dielectric-constant Na1/2La1/2Cu3Ti4O12 (NLCTO) ceramics prepared by mechanochemical synthesis and spark plasma sintering (SPS) at 850 °C, 900 °C, and 925 °C for 10 min.
H. Kotb, M. M. Ahmad, S. Ansari, T. Kayed, A. Alshoaibi   +4 more
semanticscholar   +1 more source

Strength of Association between Infarct Volume and Clinical Outcome Depends on the Magnitude of Infarct Size: Results from the ESCAPE-NA1 Trial

American Journal of Neuroradiology, 2021
BACKGROUND AND PURPOSE: Infarct volume is an important predictor of clinical outcome in acute stroke. We hypothesized that the association of infarct volume and clinical outcome changes with the magnitude of infarct size. MATERIALS AND METHODS: Data were
J. Ospel, M. Hill, B. Menon, A. Demchuk, R. McTaggart, Ricardo P Nogueira, A. Poppe, D. Haussen, W. Qiu, A. Mayank, M. Almekhlafi, C. Zerna, M. Joshi, M. Jayaraman, D. Roy, J. Rempel, B. Buck, M. Tymianski, M. Goyal   +18 more
semanticscholar   +1 more source

NA1-115-7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
The overexpression of antiapoptotic members (BCL-2, BCL-xL, MCL-1, etc.) of the BCL-2 family contributes to tumor development and resistance to chemotherapy or radiotherapy.
Florian Daressy, Line Séguy, Loëtitia Favre, S. Corvaisier, C. Apel, A. Groo, M. Litaudon, V. Dumontet, A. Malzert‐Fréon, Sandy Desrat, F. Roussi, Aude Robert, J. Wiels   +12 more
semanticscholar   +1 more source

Effects of Sintering Conditions on Giant Dielectric and Nonlinear Current–Voltage Properties of TiO2-Excessive Na1/2Y1/2Cu3Ti4.1O12 Ceramics

Molecules, 2022
The effects of the sintering conditions on the phase compositions, microstructure, electrical properties, and dielectric responses of TiO2-excessive Na1/2Y1/2Cu3Ti4.1O12 ceramics prepared by a solid-state reaction method were investigated.
Pariwat Saengvong, Jakkree Boonlakhorn, N. Chanlek, Nutthakritta Phromviyo, Viyada Harnchana, P. Moontragoon, P. Srepusharawoot, S. Krongsuk, P. Thongbai   +8 more
semanticscholar   +1 more source

Thermophilic Inorganic Pyrophosphatase Ton1914 from Thermococcus onnurineus NA1 Removes the Inhibitory Effect of Pyrophosphate

International Journal of Molecular Sciences, 2022
Pyrophosphate (PPi) is a byproduct of over 120 biosynthetic reactions, and an overabundance of PPi can inhibit industrial synthesis. Pyrophosphatases (PPases) can effectively hydrolyze pyrophosphate to remove the inhibitory effect of pyrophosphate.
Yajing Li, Xue Yang, R. Gao
semanticscholar   +1 more source