Results 151 to 160 of about 1,151,690 (319)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

盐角草(Salicornia europaea)对NaCl处理的生理响应/Responses of Physiological Traits of Salicornia european to NaCl Treatment[J]

open access: yes, 2014
用含有NaCl的Hoagland培养液处理盐角草(Salicornia europaea)11d.检测其鲜重,干重,离子含量,电导率,溶解性总同体(TDS)含量,超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)活性及丙二醛(MDA)浓度.结果表明:随着NaCl浓度的增加,盐角草干重和鲜重呈现先上升后下降的趋势,相对电导率、TDS、SOD、POD、CAT及MDA均呈现先下降后上升的趋势,在NaCl溶液浓度为200 mmol·L-1左右时,干重和鲜重的值达到最大,电导率、TDS、SOD ...
马金彪   +7 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Selective and localized micro-assembly of NaCl crystals by DEP force

open access: yes, 2008
This paper reports the experimental results of the micro-assembly of micron-sized NaCl crystals formed between gold microelectrodes using gold colloidal solution by capillary force and dielectrophoresis (DEP). Typical NaCl crystals formed and manipulated
Qu YL(曲艳丽)   +3 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Temperature extension of NaCl Pitzer coefficients and ∆RG°(NaCl)

open access: yes, 2020
The general temperature range for THEREDA is currently limited to 0 to about 110°C. For the important electrolyte NaCl there are thermodynamic data available to 200°C and above. To cover this larger temperature range for the Pitzer coefficients, a refit of the temperature functions of Greenberg, J. P. and Møller, N. (Geochim. Cosmochim.
openaire   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

蕹菜和豆瓣菜对NaCl盐胁迫的响应

open access: yes, 2013
在蕹菜和豆瓣菜种子萌发期间,用7种不同浓度的NaCl溶液胁迫处理,分析不同浓度盐胁迫下种子萌发指标和幼苗生长指标的变化,比较蕹菜和豆瓣菜对盐胁迫的响应。试验结果表明,随NaCl浓度增加,蕹菜和豆瓣菜的种子萌发指标均呈下降趋势。蕹菜在1.5%NaCl胁迫下,仍有24%的萌发率,而豆瓣菜在0.9%以上的NaCl胁迫下,种子完全不能萌发;低浓度NaCl促进豆瓣菜幼苗根和芽的生长,而对蕹菜幼苗的影响不显著,当NaCl浓度超过0.6%时,显著抑制蕹菜幼苗生长;NaCl浓度超过0.3%,显著抑制豆瓣菜幼苗的生长 ...
李为, 万茜, 张凤银
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

NaCl处理对多枝柽柳(Tamarix ramosissima)生长及生理的影响/Effects of NaCl Treatments on Growth and Eco-physiological Characteristics of Tamarix ramosissima[J]

open access: yes, 2014
以1年生多枝柽柳(Tamarix ramosissima)幼株为材料,采用盆栽试验研究不同浓度(0、50、100、200、400mmol·L-1)NaCl处理对多枝柽柳生长状况及叶片过氧化氢(H2O2)、丙二醛(MDA)含量,超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、过氧化物酶(POD)、抗坏血酸过氧化物酶(APX)活性,水势,可溶性糖和脯氨酸含量的影响.结果表明:低浓度(≤100mmol· L-1)的NaCl处理对多枝柽柳株高、冠幅面积、分枝数和叶、枝干重具有促进效应;高浓度(≥200 mmol
鲁艳   +14 more
core  

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