Results 131 to 140 of about 192,695 (172)
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Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+
Nature MetabolismThe coenzyme NAD+ is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD+ levels, but how cells cope with persistently decreased NAD+ concentrations is unclear.
Lena E. Høyland +23 more
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Archives of Disease in Childhood, 2017
It’s rare for a single paper to claim to have not only discovered a new mechanism for disease but also a means of preventing it. A paper from Sydney, Australia, which at first sight appears somewhat obscure and theoretical, does just that (Shi H et al. NEJM 2017. doi: 10.1056/NEJMoa1616361). It combines genetic studies on four families with mouse model
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It’s rare for a single paper to claim to have not only discovered a new mechanism for disease but also a means of preventing it. A paper from Sydney, Australia, which at first sight appears somewhat obscure and theoretical, does just that (Shi H et al. NEJM 2017. doi: 10.1056/NEJMoa1616361). It combines genetic studies on four families with mouse model
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NAD+ Availability and Proteotoxicity
NeuroMolecular Medicine, 2009It has been shown that NAD(+) availability is important for neuronal survival following ischemia (Liu et al., Neuromolecular Med 11:28-42, 2009). It is proposed here that NAD(+) may also control proteotoxicity by influencing both formation and catabolism of altered proteins.
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Regulation of NAD+ metabolism in aging and disease
Metabolism: Clinical and Experimental, 2022Raghavan Raju, Xiaogang Chu
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Role of NAD+ in regulating cellular and metabolic signaling pathways
Molecular Metabolism, 2021Puneet Bagga +2 more
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Nicotinamide adenine dinucleotide (oxidized form, NAD+) serves as a co-substrate and co-enzyme in cells to execute its key roles in cell signalling pathways and energetic metabolism, arbitrating cell survival and death. It was discovered in 1906 by Arthur Harden and William John Young in yeast extract which could accelerate alcohol fermentation.
Jared, Rice +2 more
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Jared, Rice +2 more
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NAD + homeostasis in human health and disease
EMBO Molecular Medicine, 2021Ronald Wanders +2 more
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SPAAC-NAD-seq, a sensitive and accurate method to profile NAD + -capped transcripts
Proceedings of the National Academy of Sciences of the United States of America, 2021Xufeng Wang, Hao Hu, Zhulong Chan
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