Glucose metabolism in the pathogenic free‐living amoebae: Tempting targets for treatment development
Chemical Biology &Drug Design, Volume 103, Issue 1, January 2024.Enzymes involved in glucose metabolism may be promising therapeutic targets for drug development against the pathogenic free‐living amoebae. Details about the enzyme sequence and structural properties make a compelling case for designing small molecule inhibitors that are specific to the amoebae and would not affect the host enzyme.AbstractPathogenic ...
Jillian E. Milanes +8 more
wiley +1 more source
Trogocytosis by Entamoeba histolytica Mediates Acquisition and Display of Human Cell Membrane Proteins and Evasion of Lysis by Human Serum. [PDF]
, 2019 We previously showed that Entamoeba histolytica kills human cells through a mechanism that we termed trogocytosis ("trogo-" means "nibble"), due to its resemblance to trogocytosis in other organisms. In microbial eukaryotes like E.
Miller, Hannah W +2 more
core +1 more source
Virulence-related protein synthesis in Naegleria fowleri [PDF]
Infection and Immunity, 1991 Protein synthesis patterns of the low-virulence Naegleria fowleri LEE strain from axenic culture, the same strain after mouse brain passage to increase virulence, and the same strain after growth on bacteria were studied. Comparisons of accumulated proteins, in vivo-synthesized proteins, and in vitro-synthesized proteins translated from poly(A)+ mRNA ...
R N Band, W J Kopachik, W N Hu
openaire +3 more sources
Cholera Toxin Subunit B as Adjuvant--An Accelerator in Protective Immunity and a Break in Autoimmunity [PDF]
, 2015 Cholera toxin subunit B (CTB) is the nontoxic portion of cholera toxin. Its affinity to the monosialotetrahexosylganglioside (GM1) that is broadly distributed in a variety of cell types including epithelial cells of the gut and antigen presenting cells ...
Stratmann, Thomas
core +2 more sources
In Vitro Evaluation of Farnesyltransferase Inhibitor and its Effect in Combination with 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor against Naegleria fowleri. [PDF]
, 2020 Free-living amoeba Naegleria fowleri causes a rapidly fatal infection primary amebic meningoencephalitis (PAM) in children. The drug of choice in treating PAM is amphotericin B, but very few patients treated with amphotericin B have survived PAM ...
Debnath, Anjan, Hahn, Hye
core +1 more source
Lethal encounters: The evolving spectrum of amoebic meningoencephalitis
IDCases, 2019 The free-living amoebae are thermophilic organisms that may play an increasing role among diseases of a warming world. They are uncommon, accidental, yet high consequence pathogens, with differing pathologic syndromes.
Sandra G. Gompf, Cristina Garcia
doaj +1 more source
PLoS Neglected Tropical Diseases, 2020 Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice +4 more
doaj +1 more source
A preliminary study on Naegleria species in water bodies of Kurunegala district, Sri Lanka
Sri Lankan Journal of Infectious Diseases, 2018 Introduction and Objective: Species belonging to the genus Naegleria are free-living ubiquitous protozoa. They have been isolated from most regions of the world. N.
JANS Gunarathna +2 more
doaj +1 more source
Naegleria fowleri in Pakistan [PDF]
The Lancet Infectious Diseases, 2020 Syed Babar Jamal +2 more
openaire +3 more sources
LABRAD : Vol 38, Issue 2 - December 2012 [PDF]
, 2012 Automation in Microbiology Specimen Processing and Inoculation Use of Automated Urine Analyzer for Urinanalysis Automation in Blood Culture Vitek 2 System: An Automated System for Antimicrobial Susceptibility Testing TB Diagnosis-A New Horizon ...
Aga Khan University Hospital, Karachi
core +1 more source