Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva +5 more
wiley +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Correction: Multi-modal dataset creation for federated learning with DICOM-structured reports. [PDF]
Tölle M +23 more
europepmc +1 more source
SWOT-Analyse und Handlungsexpertise. Themenfeld Leistungssport in Chemnitz/Sportforum [PDF]
Nagel, Siegfried +2 more
core
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
Who Will Evolve from Interstitial Lung Abnormalities to Interstitial Lung Disease? Early Radio-Proteomic Warning Signals in the Lung. [PDF]
Nagel DJ, Valenzi E.
europepmc +1 more source
When Nature Talks, Markets Move: Forecasting the Equity Premium With Eco‐Climate Incidents
ABSTRACT This paper examines the role of eco‐climate information, particularly biodiversity risks, in forecasting the U.S. equity premium. Using RepRisk controversy data, we construct indicators for biodiversity, greenhouse gas emissions, and local pollution. Biodiversity indicators emerge as strong predictors of the equity premium, outperforming other
Zhiyong Li, Weiping Qin
wiley +1 more source
Impact of 85 kHz versus 125 kHz SHIFT OCTA scan speeds on image quality in retinal diseases and diagnostic reliability of choroidal neovascular membranes. [PDF]
Tran MD +10 more
europepmc +1 more source
ABSTRACT Using pikeperch (Sander lucioperca) as a model species, we investigated the factors influencing fluctuations in the abundance of piscivorous intra‐annual cohorts and assessed the role of three distinct cohorts: extremely small (ES), ordinary (or mid‐sized) fingerlings, and piscivorous in shaping year‐class strength.
Million Tesfaye +21 more
wiley +1 more source

