Results 61 to 70 of about 150,868 (264)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Prevalence of temporomandibular disorders and its association with parafunctional habits among senior-secondary school children of Lucknow, India

Journal of Indian Association of Public Health Dentistry, 2016
Introduction: Temporomandibular disorders (TMD) are defined as heterogeneous group of psychological disorders, commonly characterized by orofacial pain, chewing dysfunction, or both. Aim: To determine the prevalence of TMD and to describe the association
Kriti Agarwal, Sabyasachi Saha, Pooja Sinha   +2 more
doaj   +1 more source

Evaluating psychodynamic therapy for nail picking and biting: An approach to body focused repetitive behaviors. [PDF]

Skin Res Technol
Tan IJ, Agarwal P, Nakell SK, Jafferany M.   +3 more
europepmc   +2 more sources

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Efficacy of AEBT in Reducing Anxiety and Experimental avoidance of Body Focused Repetitive Behavior Disorders with three month follow up

فصلنامه دانشگاه علوم پزشکی جهرم, 2018
purpose of this study was to evaluate the effectiveness of AEBT therapy on reducing anxiety and experiencing avoidance of Mixed Trichotillomania، Skin picking disorder and Nail biting with three month follow up This study was a single-subject ...
zinab khanjani, toraj hashemi, majid mahmodailou, pariya faroghi   +3 more
doaj  

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Onychophagia (nail biting): a body focused repetitive behavior due to psychiatric co-morbidity

Psychiatry and Behavioral Sciences, 2017
Onychophagia is an habit of biting one’s nails and finger tips. It is also called nail biting (NB). It is a stress relieving oral habit adopted by many children and adults. People usually do it when they are nervous, stressed, hungry or bored.
DR.JAVED ATHER SIDDIQUI, DR.SHAZIA FARHEEN QURESHI, DR.WASEEM M MAREI, DR. TALAL ABDULLAH MAHFOUZ   +3 more
doaj   +1 more source

Intellectual Disability and Multiple Co Morbid Psychiatric Disorders in a Child: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2014
Comorbid psychiatric Disorders are seen commonly in people with intellectual disability and in fact they are at greater risk for developing other health disorders.
Priyanka Gautam, M.S.Bhatia, Anubhav Rathi   +2 more
doaj   +1 more source

Deep Volumetric Super‐Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM

Advanced Science, EarlyView.
Sparse scanning structured illumination microscopy (SS‐SIM) extends the axial depth in super‐resolution fluorescence imaging by combining rapid laser scanning, pixel‐addressed intensity modulation, and sCMOS camera detection. SS‐SIM yields 1.6× lateral and 1.7× axial resolution gains over wide‐field microscopy and enables imaging through 300–600 µm ...
Sha An, Xuhong Guo, Zhongxia Cai, Yunze Lei, Kai Wen, Hongfei Suo, Xiaoyu Kong, Gerd Ulrich Nienhaus, Peng Gao   +8 more
wiley   +1 more source

The Bitter Taste of Brazil's Temporary Import Ban on Robusta Coffee

Agribusiness, EarlyView.
ABSTRACT Brazil, a leading Robusta coffee producer and exporter, faced a significant drought in 2016–2017, which drastically reduced production and depleted stocks. Consequently, Brazil temporarily permitted the import of one million 60‐kg bags of Robusta coffee in the spring 2017. An import ban was imposed shortly afterward due to lobbying by domestic
Hanifi Otgun, John Beghin, Fernando Maximiliano   +2 more
wiley   +1 more source