Results 191 to 200 of about 180,929 (353)

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

Vitamins for the Management of Nail Disease: A Literature Review. [PDF]

Skin Appendage Disord
Curtis KL, Lipner SR.
europepmc   +1 more source

Development of the High Sensitive Separation Analysis Method of Metabolites in Human Nail and its Application to the Diagnosis of Chronic Disease

, 2014
Jun Zhe Min
openalex   +2 more sources

Nail‑Patella syndrome with early onset end‑stage renal disease in a child with a novel heterozygous missense mutation in the LMX1B homeodomain: A case report

, 2020
Soledad Carinelli, Olalla Álvarez Blanco, Ana Perdomo-Ramírez, Félix Claveríe‐Martín   +3 more
openalex   +2 more sources

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Nail Disease in a Nail Consultation at a Tertiary Referral Center: A 10-Year Retrospective Study. [PDF]

Skin Appendage Disord
Rosca A, Magalhães C, Matos J, Teixeira D, Guedes R.   +4 more
europepmc   +1 more source

Clinical improvement in psoriatic nail disease and psoriatic arthritis with tildrakizumab treatment

, 2020
Fathima Ferial Ismail, John May, John Hsing-Yih Moi, Rodney Sinclair   +3 more
openalex   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Nail and hair changes in chronic kidney disease patients

, 2020
Jogendra Singh
openalex   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source