Results 191 to 200 of about 77,096 (260)

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Epidermolysis Bullosa Classification and Current Approach to Diagnosis. [PDF]

Pediatr Dermatol
Mumber HE, Perman MJ.
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Resistance and Recalcitrance in Dermatophytosis: Mechanistic and Clinical Considerations for Keratinized Tissues. [PDF]

Antibiotics (Basel)
Valdez-Martinez A, Arenas R, Moreno-Salinas A, Perez-Tristan M, Gomez-Rico MJ, Torres-Olguín I, Fuentes-Venado CE, Bastida-González F, Martínez-Herrera E, Pinto-Almazán R.   +9 more
europepmc   +1 more source

Tildrakizumab in the Treatment of Complex and Severe Psoriasis: A Case Series. [PDF]

J Clin Med
Marasca C, D'Amico D, Giofrè C, Lora V.
europepmc   +1 more source

Subungual Myiasis Presenting to the Emergency Department: A Case Report. [PDF]

Clin Pract Cases Emerg Med
Marquis TD, Sheng AY.
europepmc   +1 more source

Custom Antibiotic-Coated Intramedullary Nails for Infected Tibial and Femoral Nonunions: Retrospective Cohort Study and Surgical Technique. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Chow VJ, Mannambeth R.
europepmc   +1 more source

Case Report: Successful topical simvastatin therapy in a 2-year-old girl with keratin 16-associated palmoplantar epidermal differentiation disorder. [PDF]

Front Pediatr
Zhong Q, Zhang Y, Feng Z, Zhang J, Chen B.   +4 more
europepmc   +1 more source

Subungual onycholemmal cysts presenting as longitudinal leukonychya: a case report and review of literature. [PDF]

An Bras Dermatol
Mc Causland MPM, Meléndez Hernández AM, Hiromi JCL, Caycedo ID.   +3 more
europepmc   +1 more source