Results 21 to 30 of about 77,096 (260)

Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index

Frontiers in Medicine
ObjectiveTo improve and validate a convolutional neural network (CNN)-based model for the automated scoring of nail psoriasis severity using the modified Nail Psoriasis Severity Index (mNAPSI) with adequate accuracy across all severity classes and ...
Stephan Kemenes, Stephan Kemenes, Liu Chang, Maja Schlereth, Rita Noversa de Sousa, Rita Noversa de Sousa, Ioanna Minopoulou, Pauline Fenzl, Pauline Fenzl, Giulia Corte, Giulia Corte, Melek Yalcin Mutlu, Melek Yalcin Mutlu, Michael Wolfgang Höner, Michael Wolfgang Höner, Ioannis Sagonas, Ioannis Sagonas, Birte Coppers, Birte Coppers, Anna-Maria Liphardt, Anna-Maria Liphardt, David Simon, Arnd Kleyer, Lukas Folle, Michael Sticherling, Michael Sticherling, Georg Schett, Georg Schett, Andreas Maier, Filippo Fagni, Filippo Fagni   +30 more
doaj   +1 more source

Comparative study of clinical and dermoscopic features in nail psoriasis

Indian Dermatology Online Journal, 2020
Background, Aims, and Objectives: Nail changes have been reported in approximately 40% of psoriasis patients. Occasionally nail psoriasis may be the sole finding or the first presentation of the disease.
Naphisabet Wanniang, Annam Navya, Varadraj Pai, Rakhi Ghodge   +3 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Nail Involvement in Alopecia Areata: A Questionnaire-based Survey on Clinical Signs, Impact on Quality of Life and Review of the Literature

Acta Dermato-Venereologica, 2017
Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes ...
Yvonne B.M. Roest, Henriët van Middendorp, Andrea W.M. Evers, Peter C.M. van de Kerkhof, Marcel C. Pasch   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Janus kinase inhibitors for nail lichen planus: A systematic review

JAAD Reviews
Background: Nail lichen planus (NLP) is a variant of lichen planus that responds inconsistently to corticosteroids, retinoids, and immunosuppressants. Its pathogenesis involves interferon-γ signaling through JAK2/STAT1, making JAK inhibition a targeted ...
Shayan Khwaja, BS, Dongwon Lee, BS, Gerardo Guilarte, BS, Sonal Choudhary, MD   +3 more
doaj   +1 more source