Results 51 to 60 of about 180,929 (353)

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Reflectance confocal microscopy for the diagnosis of skin infections and infestations [PDF]

, 2020
Reflectance confocal microscopy (RCM) is a noninvasive real-time imaging technique that has been widely used for the diagnosis of skin cancer. More recently, it has been reported as a useful tool for the diagnosis and management of several inflammatory ...
Arzberger, Edith, Bastos, Pedro Mendes, Ferreira, João, Leal-Filipe, Paulo, Oliveira, André Laureano, Pimenta, Rita, Soares-de-Almeida, Luís   +6 more
core  

Provision of foot health services for people with rheumatoid arthritis in New South Wales: a web-based survey of local podiatrists [PDF]

, 2013
Background: It is unclear if podiatric foot care for people with rheumatoid arthritis (RA) in New South Wales (NSW) meets current clinical recommendations. The objective of this study was to survey podiatrists' perceptions of the nature of podiatric foot
A Blake, A Williams, AC Redmond, AE Williams, AE Williams, AE Williams, AF Marsman, Arthritis and Musculoskeletal Alliance, AS Graham, CJ Bowen, CM Sofka, DE Turner, DE Turner, GJ Hendry, GJ Hendry, Gordon J Hendry, J Firth, J Michelson, J Woodburn, Joshua Burns, JS Smolen, K Hennessy, K Rome, K Rome, Kathryn A Gibson, Keith Rome, Kevin Pile, KL Manfreda, Luke Taylor, M van der Leeden, M van der Leeden, MA D'Agostino, MR Backhouse, National Collaborating Centre for Chronic Conditions, O Wilson, P Helliwell, Podiatry Rheumatic Care Association, R Luqmani, RJ Wakefield, SIG Network, SM Bergin, The Royal College of General Practitioners, Verona du Toit, W Fan   +43 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Twenty nail onychomadesis following acute viral hepatitis B infection

Journal of Marine Medical Society, 2020
Onychomadesis is a nail plate abnormality with temporary cessation in the growth of the nail plate due to disturbances in the nail matrix. Any local or systemic condition affecting the nail matrix directly or indirectly can lead to onychomadesis.
M Sivasankari, Preema Sinha
doaj   +1 more source

THE NAILS AS AN INDEX OF DISEASE. [PDF]

The Lancet, 1896
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openaire   +2 more sources

Use of sonic tomography to detect and quantify wood decay in living trees. [PDF]

, 2016
Premise of the studyField methodology and image analysis protocols using acoustic tomography were developed and evaluated as a tool to estimate the amount of internal decay and damage of living trees, with special attention to tropical rainforest trees ...
Ballesteros, Javier O, Barrick, Pablo P, Barrios-Rodriguez, Cesar A, Bonadies, Ernesto F, Burgos, Alana C, Cedeño-Sánchez, Marjorie L, Chester, Kathleen N, Diab, Jonathan H, Faircloth, Brant C, Fossatti-Caballero, Nohely J, Fábrega, Juan Pablo, García-López, Cesar G, Gilbert, Gregory S, Glenn, Travis C, Harrower, Jennifer T, Henn, Laura AW, Hershcovich, Shiran, Holub-Young, Katharine S, Hooton, Douglas A, Hubbell, Stephen P, Johnston, Daniel C, Jordan, Fulvia A, Lumpkin, Raleigh, McWilliams, Hunter A, Pérez-Suñiga, José Moises, Renteria, Sonia A, Romo, Amanda C, Russo, Natalie, Sánchez, Juan David, Thompson, Jennifer B, Trejos-Rodríguez, Mariam M, Wong, E Beatriz   +31 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Emerging Topical and Systemic JAK Inhibitors in Dermatology [PDF]

, 2019
Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders.
Ghoreschi, Kamran, Meier, Katharina, Solimani, Farzan   +2 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source