Results 61 to 70 of about 71,479 (314)

Diagnostic utility of onychoscopy: Review of literature

open access: yesIndian Journal of Dermatopathology and Diagnostic Dermatology, 2017
Onychoscopy is being increasingly used as a diagnostic modality for various nail diseases. Initial research had focused mainly on nail pigmentation and nailfold capillaroscopy; however, it is now being evaluated in various infectious and inflammatory ...
Chander Grover, Deepak Jakhar
doaj   +1 more source

Post-Traumatic Ectopic Nail: A Case Report and Review of Literature [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
Ectopic nail or Onychoheterotopia is an uncommon clinical entity. They are usually congenital; the acquired variety is very rare. The exact pathogenesis of the disease is not clear.
Susanta Meher   +4 more
doaj   +1 more source

Nail-patella syndrome (Fong disease) [PDF]

open access: yesPediatric Radiology, 2010
A14-year-oldboypresentedtotheorthopedicclinicfornon-painful elbow deformities. Knee radiographs demonstratedsmall patellae (Fig. 1). Elbow radiographs showed disloca-tion of the right radial head (Fig. 2). Pelvic radiograph wasnormal. Physical exam revealed bilateral absence of nailson the thumb and index fingers.
Scott A, Mooney, Johnny U V, Monu
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Optimal management of nail disease in patients with psoriasis

open access: yesPsoriasis: Targets and Therapy, 2015
Bianca Maria Piraccini, Michela Starace Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: Psoriasis is a common skin disease, with nail involvement in approximately 80%
Piraccini BM, Starace M
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Clinical Diagnosis and Laboratory Testing of Abnormal Appearing Toenails: A Retrospective Assessment of Confirmatory Testing for Onychomycosis in the United States, 2022–2023

open access: yesJournal of Fungi
Onychomycosis is an under-recognized healthcare burden. Despite the risk of misdiagnosis, confirmatory laboratory testing is under-utilized. Histopathologic examination with polymerase chain reaction (PCR) is currently the most effective diagnostic ...
Aditya K. Gupta   +6 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Tofacitinib successful treatment of idiopathic twenty-nail dystrophy: a case report

open access: yesJournal of Dermatological Treatment
Purpose Twenty-nail dystrophy (TND) is a chronic nail disorder affecting all or some nails and posing a significant therapeutic challenge for dermatologists.
Wenjun Zhao, Shijun Shan, Dongmei Liu
doaj   +1 more source

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