Results 71 to 80 of about 71,479 (314)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nail Abnormalities in Thai Psoriasis Patients with Disease Severity and Impact on Quality of Life
Siriraj Medical Journal, 2014 Background: Nail abnormalities are common in psoriasis. The relationship between nail abnormalities and disease severity or impact on quality of life has scarcely been reported. Objectives: The aims of this study were to find the proportion and types of
Sukhum Jiamton +7 more
doaj
The impact of Hashimoto’s disease on skin, hair, and nails [PDF]
, 2021 Olga Koczorowska-Talarczyk +1 more
openalex +1 more source
Nail disease in pemphigus vulgaris
Dermatology Online Journal, 2009 Patients affected by pemphigus vulgaris will occasionally present with associated and characteristic nail changes. This manuscript was prepared as a review of this unique presentation of pemphigus. Articles describing pemphigus vulgaris of the nail were compiled and reviewed and pertinent information was extracted to provide a concise analysis.
Serratos, Brittany Dusek +1 more
openaire +4 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
New insight into the pathogenesis of nail psoriasis and overview of treatment strategies
Drug Design, Development and Therapy, 2017 Alessandra Ventura,1 Mauro Mazzeo,1 Roberta Gaziano,2 Marco Galluzzo,1 Luca Bianchi,1 Elena Campione1 1Department of Dermatology, University of Rome “Tor Vergata”, Rome, Italy; 2Department of Experimental Medicine and Surgery, Rome, Italy ...
Ventura A +5 more
doaj
Ingrown toenail: pathogenesis, prevention and conservative treatment
Przegląd Dermatologiczny, 2015 Ingrown toenail is a disease of both children and adults, causing discomfort or pain of varying degrees of severity. Depending on the stage of disease, it is often the cause of significant difficulties in daily life.
Paweł P. Antończak +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Acta Dermato-Venereologica, 2018 Little is known about the relationship between nail psoriasis and psoriasis severity in children, and there has been no longitudinal assessment of psoriasis severity related to nail psoriasis.
Inge M.G.J. Bronckers +8 more
doaj +1 more source