Results 171 to 180 of about 204,698 (232)

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Conventional one-handed compared to two-handed endoscopic ear surgery using an endoscope holder: a single center study. [PDF]

Eur Arch Otorhinolaryngol
Müller C, Raczynski A, Lailach S, Zahnert T.   +3 more
europepmc   +1 more source

Geometry‐Encoded Soft Strain Sensing via Liquid‐Metal Transmission Lines

Advanced Science, EarlyView.
This study presents a liquid‐metal transmission‐line strain sensor that achieves intrinsic decoupling by encoding axial elongation into propagation delay. The time‐domain readout remains stable under complex off‐axis. This enables reliable, repeatable, real‐time elongation measurement in dynamic, multiaxial loading environments for wearable electronics,
Zhang Liu, Fengdeng Jin, Wenxuan Shi, Meng She, Ziqi Meng, Miao Fang, Yixin Zhang, Qianwen Dong, Wandi Yang, Lei Shi, Xujia Zhao, Feng Zhou, Bin Yao   +12 more
wiley   +1 more source

Clinical Outcomes And Risk Factors In Patients Circumcised By Chinese Shang Ring: A Prospective Study Based On Age And Types Of Penile Disease. [PDF]

Ther Clin Risk Manag, 2019
Wang H, Huang Z, Zhou J, Zhang X, Liang C.   +4 more
europepmc   +1 more source

Strengthening Constitutive Motifs in Isotropic Fibrous Hydrogel for Exceptional Damage Resistance

Advanced Science, EarlyView.
An orientation‐free strategy is reported for fabricating damage‐resistant hydrogels by strengthening constitutive motifs in isotropic fibrous (IF) networks. Through nonsolvent quenching followed by salting‐out, IF networks are generated and their multiscale constituents are subsequently reinforced, yielding dense and crystalline isotropic nanofiber ...
Bolin Wan, Xule Yang, Liju Xu, Dong Qiu
wiley   +1 more source

A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions. [PDF]

Mol Cell, 2019
Ahler E, Register AC, Chakraborty S, Fang L, Dieter EM, Sitko KA, Vidadala RSR, Trevillian BM, Golkowski M, Gelman H, Stephany JJ, Rubin AF, Merritt EA, Fowler DM, Maly DJ.   +14 more
europepmc   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

A Biomechanical Assessment of Hand/Arm Force with Pneumatic Nail Gun Actuation Systems. [PDF]

Int J Ind Ergon, 2014
Lowe BD, Albers J, Hudock SD.
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source