Results 191 to 200 of about 3,029,584 (248)

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Stress Distribution in Interlocking and Blocking Screw Fixation for Distal Tibial Intramedullary Nailing: A Finite Element Analysis. [PDF]

J Clin Med
Jung GH, Jeong SL, Ahn J.
europepmc   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

A catalytically polymerized solid electrolyte enables 450 Wh kg^-1 lithium-metal batteries with thermal-mechanical abuse tolerance. [PDF]

Nat Commun
Tang J, Zhang J, Liu J, Li Y, Shao A, Wang Z, Wang X, Jia Q, Liu T, Liu Z, Wang JG, Wang Z, Xu F, Ma Y.   +13 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Chemical Composition, Biological Activities and Application of <i>Lupinus angustifolius</i> in Cosmetics and Food Industry. [PDF]

Molecules
Jakobina M, Galek R, Preisner M.
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Access to operative fracture fixation resources and implants in orthopaedic trauma care in low- and middle-income countries: a systematic review. [PDF]

OTA Int
Tiondi HR, Kruse C, Yan JR, Bhandari M, Petrisor B.   +4 more
europepmc   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Work-Related Musculoskeletal Disorders and Occupational Burnout Among Pet Grooming Professionals: Prevalence, Ergonomic Risk Factors, and Their Interrelationships. [PDF]

Healthcare (Basel)
Cheng SH, Chen MR, Tsai CJ.
europepmc   +1 more source