Results 51 to 60 of about 3,029,584 (248)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A finite element strategy applied to intramedullary nailing of the proximal femur [PDF]
, 2005 This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.An intramedullary nail is a trauma treatment device used for fracture fixation of long bones. These devices are subject to failure, including lag screw
Simpson, David John
core +5 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Nailed It: Producing and Consuming in Tokyo's Nail Industry [PDF]
, 2012 This study, supported by public observation, interviews, and analysis of Japanese fashion and nail magazines, looks at the role of the Tokyo nail industry in the shaping of Japanese women's bodies.
Scofield, Rebecca,, Scofield, Rebecca
core +1 more source
Implementation of the Design Thinking Method in the UI/UX Design of the Bellina Studio Website
Sistemasi: Jurnal Sistem InformasiThe rapid growth of the beauty industry demands effective digital marketing strategies, including optimal website UI/UX design. This study explores the UI/UX design of the Bellina Studio website using the Design Thinking method to enhance user experience.
Destya Ayu Sinta Putri, Adi Nugroho
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
The Clinical Features of Nail Psoriasis
, 2014 Nail involvement is present in over half of patients with psoriasis and consequently has a prominently negative impact on society. The clinical gamut of nail involvement is diverse and includes changes to the nail matrix, the nail bed, or both.
Antonella Tosti +3 more
core +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Anatomy of the nail unit and the nail biopsy [PDF]
, 2015 The nail unit is the largest and a rather complex skin appendage. It is located on the dorsal aspect of the tips of fingers and toes and has important protective and sensory functions. Development begins in utero between weeks 7 and 8 and is fully formed
Haneke, Eckart
core +1 more source
Meitan kexue jishuElectrification and intellectualization are the inevitable trends in the development of mining equipment, and explosion-proof lithium battery power supplies represent a critical technical approach for the “oil-to-electricity” conversion of mobile heavy ...
Caiyun ZANG +5 more
doaj +1 more source