Results 91 to 100 of about 1,510,953 (378)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The metal finds and their implications [PDF]

open access: yes, 2012
Major interdisciplinary study of metal artefacts from major Norse site in ...
Barrett, J.H.   +3 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Observation on the therapeutic effect of decompression surgery with proximal nail plate trephination in 61 cases of subungual hematoma

open access: yesPifu-xingbing zhenliaoxue zazhi
[Objective] To explore the clinical effect and prognosis of decompression surgery with proximal nail plate trephination for the treatment of subungual hematoma. [Methods] A total of 61 patients with subungual hematoma treated at the Dermatology Clinic of
WANG Huafeng   +5 more
doaj   +1 more source

Reproducibilty of partial weight bearing [PDF]

open access: yes
Objectives: To find out whether partial weight bearing can be reproduced and retained. Design: In vivo experiment in normal subjects. Intervention: Training for partial weight bearing (25% of body weight) using bathroom scales.
Doyle, J   +4 more
core   +1 more source

Prospective and randomized study of patients with open fractures of the femoral shaft, treated with plate or open intramedullary locked nail [PDF]

open access: yes, 2008
We assessed the complications and treatment outcomes in a prospective and randomized study of two osteosynthesis techniques in open femoral shaft fractures.
Belloti, Joao Carlos   +5 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

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